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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc31tm1.1Aru
targeted mutation 1.1, Anil K Rustgi
MGI:5560203
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mirc31tm1.1Aru/Mirc31tm1.1Aru
Tg(Vil1-cre)997Gum/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL MGI:5560214
cn2
 		Mirc31tm1.1Aru/Mirc31tm1.1Aru
Tg(Vil1-cre)997Gum/0
Tg(Vil1-Lin28b,-tdTomato)LoAru/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL MGI:5560215


Genotype
MGI:5560214
cn1
Allelic
Composition		 Mirc31tm1.1Aru/Mirc31tm1.1Aru
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc31tm1.1Aru mutation (0 available); any Mirc31 mutation (2 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestine morphology ( J:202923 )
• modest but significant intestinal hypertrophy
abnormal crypts of Lieberkuhn morphology ( J:202923 )
• increase in the fraction of fissile crypts
decreased Paneth cell number ( J:202923 )
• modest decrease in the number of Paneth cells

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:202923 )
• increase in the fraction of fissile crypts
decreased Paneth cell number ( J:202923 )
• modest decrease in the number of Paneth cells




Genotype
MGI:5560215
cn2
Allelic
Composition		 Mirc31tm1.1Aru/Mirc31tm1.1Aru
Tg(Vil1-cre)997Gum/0
Tg(Vil1-Lin28b,-tdTomato)LoAru/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc31tm1.1Aru mutation (0 available); any Mirc31 mutation (2 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Tg(Vil1-Lin28b,-tdTomato)LoAru mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal crypts of Lieberkuhn morphology ( J:202923 )
• crypt hyperplasia and expanded crypts
decreased Paneth cell number ( J:202923 )
• significant reduction in the number of Paneth cells

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:202923 )
• crypt hyperplasia and expanded crypts
decreased Paneth cell number ( J:202923 )
• significant reduction in the number of Paneth cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory