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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Habp2tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:5560205
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Habp2tm1Lex/Habp2tm1Lex involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:5562291


Genotype
MGI:5562291
hm1
Allelic
Composition		 Habp2tm1Lex/Habp2tm1Lex
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Habp2tm1Lex mutation (1 available); any Habp2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:207454 )
• 1 of 11 mice die following bile duct ligation compared with 6 of 11 wild-type mice

liver/biliary system
liver inflammation ( J:207454 )
• following bile duct ligation
liver fibrosis ( J:207454 )
• following bile duct ligation or CCl4 treatment

homeostasis/metabolism
abnormal response to injury ( J:207454 )
• following bile duct ligation, mice exhibit decreased lethality and increased liver fibrosis, injury and inflammation compared with wild-type mice

immune system
liver inflammation ( J:207454 )
• following bile duct ligation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory