Phenotypes associated with this allele

• Allele Symbol: Vkorc1^tm1.1Jobg
• Allele Name: targeted mutation 1.1, Johannes Oldenburg
• Allele ID: MGI:5560512
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vkorc1^tm1.1Jobg/Vkorc1^tm1.1Jobg	involves: 129S4/SvJae * BALB/cJ * C57BL/6	MGI:5560514

Genotype
MGI:5560514

hm1

• Allelic Composition: Vkorc1^tm1.1Jobg/Vkorc1^tm1.1Jobg
• Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:207884 )

• within seven days of vitamin K withdrawal after 3 weeks of supplementation

postnatal lethality, complete penetrance ( J:207884 )

• all mice die between P1 and P20

• 50% of mice die between P6 and P9

• however, dietary supplementation with vitamin K in neonates rescues lethality

limbs/digits/tail

short humerus ( J:207884 )

• at P8

short radius ( J:207884 )

• at P8

short femur ( J:207884 )

• at P8

short fibula ( J:207884 )

• at P8

short tibia ( J:207884 )

• at P8

cardiovascular system

intracerebral hemorrhage ( J:207884 )

subdural hemorrhage ( J:207884 )

• subdural bleeding in most mice

muscle hemorrhage ( J:207884 )

• intramuscular bleeding in mice not supplemented with vitamin K

subcutaneous hemorrhage ( J:207884 )

• subcutaneous bleeding in mice following vitamin K withdrawal after 3 weeks of supplementation

homeostasis/metabolism

abnormal blood coagulation ( J:207884 )

• decreased relative activity of vitamin K-dependent blood coagulation factors

nervous system

intracerebral hemorrhage ( J:207884 )

subdural hemorrhage ( J:207884 )

• subdural bleeding in most mice

skeleton

short humerus ( J:207884 )

• at P8

short radius ( J:207884 )

• at P8

short femur ( J:207884 )

• at P8

short fibula ( J:207884 )

• at P8

short tibia ( J:207884 )

• at P8

integument

subcutaneous hemorrhage ( J:207884 )

• subcutaneous bleeding in mice following vitamin K withdrawal after 3 weeks of supplementation

muscle

muscle hemorrhage ( J:207884 )

• intramuscular bleeding in mice not supplemented with vitamin K