Phenotypes associated with this allele

• Allele Symbol: Mef2a^tm1.1Limm
• Allele Name: targeted mutation 1.1, Lisa Monteggia
• Allele ID: MGI:5560553
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mef2a^tm1.1Limm/Mef2a^tm1.1Limm	involves: 129S/SvEv * C57BL/6	MGI:5560661
cn2	Mef2a^tm1.1Limm/Mef2a^tm1.1Limm Mef2c^tm1Jjs/Mef2c^tm1Jjs Tg(Cdh5-cre/ERT2)1Rha/0	involves: 129S/SvEv * 129S6/SvEvTac	MGI:7447283
cn3	Mef2a^tm1.1Limm/Mef2a^tm1.1Limm Mef2c^tm2Eno/Mef2c^tm2Eno Mef2d^tm3Eno/Mef2d^tm3Eno Tg(GFAP-cre)25Mes/0	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:5560657
cn4	Mef2a^tm1.1Limm/Mef2a^tm1.1Limm Mef2d^tm3Eno/Mef2d^tm3Eno Tg(GFAP-cre)25Mes/0	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:5560659
cn5	Mef2a^tm1.1Limm/Mef2a^tm1.1Limm Tg(GFAP-cre)25Mes/0	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:5560660

Genotype
MGI:5560661

hm1

• Allelic Composition: Mef2a^tm1.1Limm/Mef2a^tm1.1Limm
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:207812 )

• mice exhibit no apparent abnormalities

Genotype
MGI:7447283

cn2

• Allelic Composition: Mef2a^tm1.1Limm/Mef2a^tm1.1Limm; Mef2c^tm1Jjs/Mef2c^tm1Jjs; Tg(Cdh5-cre/ERT2)1Rha/0
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

cardiovascular system

abnormal retina vasculature morphology ( J:334208 )

• reduced sprouting angiogenesis in retina at age P5 (4 days after endothelial-cell-specific KO induction): reduced vascular density and coverage in vascular plexus and reduced number of tip cells at angiogenic front

decreased angiogenesis ( J:334208 )

• reduced sprouting angiogenesis in retina at age P5 (4 days after endothelial-cell-specific KO induction): reduced vascular density and coverage in vascular plexus and reduced number of tip cells at angiogenic front

vision/eye

abnormal retina vasculature morphology ( J:334208 )

• reduced sprouting angiogenesis in retina at age P5 (4 days after endothelial-cell-specific KO induction): reduced vascular density and coverage in vascular plexus and reduced number of tip cells at angiogenic front

Genotype
MGI:5560657

cn3

• Allelic Composition: Mef2a^tm1.1Limm/Mef2a^tm1.1Limm; Mef2c^tm2Eno/Mef2c^tm2Eno; Mef2d^tm3Eno/Mef2d^tm3Eno; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

mortality/aging

premature death ( J:207812 )

• partial lethality by 5 weeks

nervous system

nervous system phenotype ( J:207812 )

N • mice exhibit normal numbers of spines per length of dendrite in pyramidal neurons

increased neuron apoptosis ( J:207812 )

• 5-fold

decreased brain size ( J:207812 )

abnormal long-term potentiation ( J:207812 )

• mice exhibit decreased input-output curve compared with wild-type mice

• however, long term potentiation is normal

enhanced paired-pulse facilitation ( J:207812 )

growth/size/body

decreased body weight ( J:207812 )

cellular

increased neuron apoptosis ( J:207812 )

• 5-fold

Genotype
MGI:5560659

cn4

• Allelic Composition: Mef2a^tm1.1Limm/Mef2a^tm1.1Limm; Mef2d^tm3Eno/Mef2d^tm3Eno; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

behavior/neurological

behavior/neurological phenotype ( J:207812 )

N • mice exhibit normal learning and memory in context- and cue-dependent fear conditioning tests, normal anxiety-related behaviors and pain sensitivity

impaired coordination ( J:207812 )

• on a rotarod

nervous system

nervous system phenotype ( J:207812 )

N • mice exhibit normal synapse number and basal synaptic transmission

enhanced paired-pulse facilitation ( J:207812 )

Genotype
MGI:5560660

cn5

• Allelic Composition: Mef2a^tm1.1Limm/Mef2a^tm1.1Limm; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

behavior/neurological

behavior/neurological phenotype ( J:207812 )

N • mice exhibit normal behavior