nervous system
• thin and sparse layer in the absence of doxycycline
• fewer glomeruli in the olfactory bulb in the absence of doxycycline
• loss of glomeruli in the dorsal region in the absence of doxycycline
• however, doxycycline treatment from E1 through P28 rescues the number of glomeruli and loss of glomeruli in the dorsal region
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• shorter along the rostro-caudal axis at 4 weeks in the absence of doxycycline
• smaller area around the eminence of the bulb over the transition to the olfactory tract in the absence of doxycycline
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• in the absence of doxycycline, single-unit spontaneous firing rate in olfactory receptor neurons is increased compared with control mice
• however, doxycycline-treatment restores normal firing rate
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