All Phenotypes Kmt2a<tm2.1Mlc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kmt2a^tm2.1Mlc
targeted mutation 2.1, Michael L Cleary
MGI:5561120

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmt2a^tm2.1Mlc/Kmt2a^tm2.1Mlc	involves: 129P2/OlaHsd * C57BL/6	MGI:5561126

Allelic Composition	Kmt2a^tm2.1Mlc/Kmt2a^tm2.1Mlc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm2.1Mlc mutation (0 available); any Kmt2a mutation (135 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice die mid-gestation

hematopoietic system

• fetal liver cells transplanted into lethally irradiated mice fail to reconstitute the hematopoietic system unlike wild-type cells

• reduced LKS compartment, which includes hematopoietic stem cells and multi-potent progenitors, in the fetal liver

cardiovascular system

hemorrhage ( J:207555 )

homeostasis/metabolism

skin edema ( J:207555 )

integument

skin edema ( J:207555 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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