All Phenotypes Oprm1<tm1.1Cgrf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Oprm1^tm1.1Cgrf
targeted mutation 1.1, Claire Gaveriaux-Ruff
MGI:5561219

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Oprm1^tm1.1Cgrf/Oprm1^tm1.1Cgrf Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129 * C57BL/6J	MGI:5562337

Allelic Composition	Oprm1^tm1.1Cgrf/Oprm1^tm1.1Cgrf Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1^tm1.1Cgrf mutation (1 available); any Oprm1 mutation (54 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:207536 )

N	• mice exhibit normal nociception thresholds, morphine-induced antinociception and tolerance to antinociception

abnormal behavioral response to addictive substance ( J:207536 )

• under inflammatory pain, mice exhibit decreased mu opiate-induced analgesia compared with control mice

• under inflammatory pain, mice exhibit decreased analgesia to the peripheral opiate loperamide compared with control mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:207536 )

N	• morphine-induced constipation is normal

integument

integument phenotype ( J:207536 )

N	• mice exhibit normal nociception thresholds, morphine-induced antinociception and tolerance to antinociception

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