Phenotypes associated with this allele

• Allele Symbol: Lss^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5561557
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lss^tm1b(KOMP)Wtsi/Lss^tm1b(KOMP)Wtsi	C57BL/6N-Lss^tm1b(KOMP)Wtsi/Bay	MGI:5757324
hm2	Lss^tm1b(KOMP)Wtsi/Lss^tm1b(KOMP)Wtsi	C57BL/6N-Lss^tm1b(KOMP)Wtsi/Ieg	MGI:6262832
ht3	Lss^tm1b(KOMP)Wtsi/Lss^+	C57BL/6N-Lss^tm1b(KOMP)Wtsi/Ieg	MGI:6262831

Genotype
MGI:5757324

hm1

• Allelic Composition: Lss^{tm1b(KOMP)Wtsi}/Lss^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Lss^{tm1b(KOMP)Wtsi}/Bay
• Cell Lines: EPD0107_5_A09

Data Sources

IMPC Data for Lss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - BCM

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - BCM

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:6262832

hm2

• Allelic Composition: Lss^{tm1b(KOMP)Wtsi}/Lss^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Lss^{tm1b(KOMP)Wtsi}/Ieg
• Cell Lines: EPD0107_5_E09

Data Sources

IMPC Data for Lss

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:6262831

ht3

• Allelic Composition: Lss^{tm1b(KOMP)Wtsi}/Lss⁺
• Genetic Background: C57BL/6N-Lss^{tm1b(KOMP)Wtsi}/Ieg
• Cell Lines: EPD0107_5_E09

Data Sources

IMPC Data for Lss

hematopoietic system

increased leukocyte cell number ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♂

IMPC - HMGU

immune system

increased leukocyte cell number ( J:211773 )

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU