Phenotypes associated with this allele

• Allele Symbol: Oprd1^tm1.1Cgrf
• Allele Name: targeted mutation 1.1, Claire Gaveriaux-Ruff
• Allele ID: MGI:5562342
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Oprd1^tm1.1Cgrf/Oprd1^tm1.1Cgrf Scn10a^tm2(cre)Jwo/Scn10a^+	involves: 129 * C57BL/6J	MGI:5562353

Genotype
MGI:5562353

cn1

• Allelic Composition: Oprd1^tm1.1Cgrf/Oprd1^tm1.1Cgrf; Scn10a^tm2(cre)Jwo/Scn10a⁺
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:208176 )

N • mice exhibit normal responses to acute noxious heat, low-threshold and noxious mechanical stimuli and chemical/early inflammatory pain in the formalin test

abnormal nociception after inflammation ( J:208176 )

• following CFA treatment, mice exhibit increased intensity and duration of mechanical allodynia compared with control mice

• however, heat hyperalgesia is normal

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:208176 )

• in a CFA-inflammatory or sciatic nerve ligation-neuropathic pain model, mice treated with systemic or intraplantar administration of the delta agonist SNC80 fail to exhibit a reduction in pain (mechanical allodynia and hyperalgesia) compared with control mice

• however, mice exhibit normal analgesic response to SNC80 during the late formalin response