Phenotypes associated with this allele

• Allele Symbol: Dclre1c^m1Brck
• Allele Name: mutation 1, Thomas Brocker
• Allele ID: MGI:5562416
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dclre1c^m1Brck/Dclre1c^m1Brck	involves: C3H * C57BL/6	MGI:5562417
hm2	Dclre1c^m1Brck/Dclre1c^m1Brck	involves: C57BL/6	MGI:5562418

Genotype
MGI:5562417

hm1

• Allelic Composition: Dclre1c^m1Brck/Dclre1c^m1Brck
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

absent B cells ( J:207533 )

absent T cells ( J:207533 )

immune system

absent B cells ( J:207533 )

absent T cells ( J:207533 )

Genotype
MGI:5562418

hm2

• Allelic Composition: Dclre1c^m1Brck/Dclre1c^m1Brck
• Genetic Background: involves: C57BL/6

immune system

immune system phenotype ( J:207533 )

N • mice exhibit normal numbers of CD11c+MHCII+ dendritic cells, CD3-NK1.1+ NK cells, CD11b+ monocytes and Gr1+ granulocytes

decreased DN1 thymic pro-T cell number ( J:207533 )

decreased DN4 thymocyte number ( J:207533 )

• absent

decreased double-positive T cell number ( J:207533 )

• hardly any double positive thymocytes

absent B cells ( J:207533 )

decreased pre-B cell number ( J:207533 )

• virtually absent

absent CD4-positive, alpha-beta T cells ( J:207533 )

absent CD8-positive, alpha-beta T cells ( J:207533 )

hematopoietic system

decreased DN1 thymic pro-T cell number ( J:207533 )

decreased DN4 thymocyte number ( J:207533 )

• absent

decreased double-positive T cell number ( J:207533 )

• hardly any double positive thymocytes

absent B cells ( J:207533 )

decreased pre-B cell number ( J:207533 )

• virtually absent

absent CD4-positive, alpha-beta T cells ( J:207533 )

absent CD8-positive, alpha-beta T cells ( J:207533 )

endocrine/exocrine glands

decreased DN1 thymic pro-T cell number ( J:207533 )

decreased DN4 thymocyte number ( J:207533 )

• absent