All Phenotypes Dclre1c<m1Brck> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Dclre1c^m1Brck/Dclre1c^m1Brck
Genetic Background	involves: C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1c^m1Brck mutation (1 available); any Dclre1c mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent B cells ( J:207533 )

absent T cells ( J:207533 )

immune system

absent B cells ( J:207533 )

absent T cells ( J:207533 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:207533 )

N	• mice exhibit normal numbers of CD11c+MHCII+ dendritic cells, CD3-NK1.1+ NK cells, CD11b+ monocytes and Gr1+ granulocytes

decreased DN4 thymocyte number ( J:207533 )

• absent

• hardly any double positive thymocytes

absent B cells ( J:207533 )

decreased pre-B cell number ( J:207533 )

• virtually absent

hematopoietic system

decreased DN4 thymocyte number ( J:207533 )

• absent

• hardly any double positive thymocytes

absent B cells ( J:207533 )

decreased pre-B cell number ( J:207533 )

• virtually absent

endocrine/exocrine glands

decreased DN4 thymocyte number ( J:207533 )

• absent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24