All Phenotypes Jak2<m1Dlbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Jak2^m1Dlbr
mutation 1, Dwayne L Barber
MGI:5562422

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jak2^m1Dlbr/Jak2^m1Dlbr	involves: 129S1/SvImJ * C57BL/6J	MGI:5562426
ht2	Jak2^m1Dlbr/Jak2⁺	involves: 129S1/SvImJ * C57BL/6J	MGI:5562425
ht3	Jak2^m1Dlbr/Jak2^tm1Jni	involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J	MGI:5562428

Allelic Composition	Jak2^m1Dlbr/Jak2^m1Dlbr
Genetic Background	involves: 129S1/SvImJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2^m1Dlbr mutation (0 available); any Jak2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:207740 )

• no viable mice are present after E14.5

hematopoietic system

anemia ( J:207740 )

• at E12.5

Allelic Composition	Jak2^m1Dlbr/Jak2⁺
Genetic Background	involves: 129S1/SvImJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2^m1Dlbr mutation (0 available); any Jak2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:207740 )

N	• bone marrow exhibits normal CFU-megakaryocyte assays • mice exhibit normal response to 5-fluorouracil and phenylhydrazine challenge

increased megakaryocyte cell number ( J:207740 )

• in the bone marrow

decreased erythrocyte cell number ( J:207740 )

• in female, but not male, mice at 8 weeks

thrombocytosis ( J:207740 )

• thrombocythemia in male and female mice at 8 weeks

Allelic Composition	Jak2^m1Dlbr/Jak2^tm1Jni
Genetic Background	involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2^m1Dlbr mutation (0 available); any Jak2 mutation (59 available)
Jak2^tm1Jni mutation (0 available); any Jak2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:207740 )

• no viable mice are present after E14.5

hematopoietic system

anemia ( J:207740 )

• at E12.5 and E14.5

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