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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte
targeted mutation 407, TaconicArtemis
MGI:5562445
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+ B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte MGI:5562529


Genotype
MGI:5562529
ht1
Allelic
Composition
Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte/Gt(ROSA)26Sor+
Genetic
Background
B6.Cg-Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm407(H1/tetO-RNAi:Large)Arte mutation (0 available); any Gt(ROSA)26Sor mutation (991 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
N
• doxycycline-treated mice do not exhibit any evidence of active necrosis or regeneration
• in some doxycycline-treated mice prior to CTX injection
• increased collagen fibrils in the endomysial space in doxycycline-treated mice injected with CTX
• in doxycycline-treated mice injected with CTX
• aggressive in doxycycline-treated mice injected with CTX
• increased skeletal muscle regeneration in doxycycline-treated mice injected with CTX

nervous system
• fragmented and irregular, consistent with impaired maturation at the ultrastructural level, in doxycycline-treated mice injected with CTX without an increase in acetylcholine receptor aggregations number and size compared with control mice

homeostasis/metabolism
• doxycycline-treated mice injected with CTX exhibit thickened muscle basement membrane, increased collagen fibrils in the endomysial space and aggressive muscular dystrophy compared with control mice

behavior/neurological
• in doxycycline-treated mice injected with CTX compared with control mice

cellular
• thickened muscle basement membrane in doxycycline-treated mice injected with CTX compared with control mice





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last database update
10/09/2024
MGI 6.24
The Jackson Laboratory