All Phenotypes Cadps<tm1.2Tfr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cadps^tm1.2Tfr
targeted mutation 1.2, Teiichi Furuichi
MGI:5562542

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cadps^tm1.1Tfr/Cadps^tm1.2Tfr Emx1^tm1(cre)Ito/Emx1⁺	B6.Cg-Emx1^tm1(cre)Ito Cadps^tm1.1Tfr Cadps^tm1.2Tfr	MGI:5562543
cn2	Cadps^tm1.1Tfr/Cadps^tm1.2Tfr Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺	B6.Cg-Ptf1a^{tm1.1(cre)Cvw} Cadps^tm1.1Tfr Cadps^tm1.2Tfr	MGI:5562545

Allelic Composition	Cadps^tm1.1Tfr/Cadps^tm1.2Tfr Emx1^tm1(cre)Ito/Emx1⁺
Genetic Background	B6.Cg-Emx1^tm1(cre)Ito Cadps^tm1.1Tfr Cadps^tm1.2Tfr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadps^tm1.1Tfr mutation (1 available); any Cadps mutation (70 available)
Cadps^tm1.2Tfr mutation (0 available); any Cadps mutation (70 available)
Emx1^tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal Golgi trans cisterna morphology ( J:204664 )

• dilated Golgi cisternae on the trans side of the Golgi stack in hippocampal CA3 pyramidal neurons and dentate gyrus granule cells

nervous system

nervous system phenotype ( J:204664 )

N	• normal synaptic vesicle density and length of postsynaptic density in dentate gyrus granule cells

abnormal dentate gyrus morphology ( J:204664 )

• dilated Golgi cisternae on the trans side of the Golgi stack in dentate gyrus granule cells

• reduction of dense core vesicle density in the presynaptic terminal in dentate gyrus granule cells

abnormal hippocampus pyramidal cell morphology ( J:204664 )

• dilated Golgi cisternae on the trans side of the Golgi stack in hippocampal CA3 pyramidal neurons

abnormal synaptic bouton morphology ( J:204664 )

• reduction of dense core vesicle density in the presynaptic terminal in dentate gyrus granule cells

Allelic Composition	Cadps^tm1.1Tfr/Cadps^tm1.2Tfr Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
Genetic Background	B6.Cg-Ptf1a^{tm1.1(cre)Cvw} Cadps^tm1.1Tfr Cadps^tm1.2Tfr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadps^tm1.1Tfr mutation (1 available); any Cadps mutation (70 available)
Cadps^tm1.2Tfr mutation (0 available); any Cadps mutation (70 available)
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:204664 )

N	• normal basic synaptic transmission, short-term plasticity, and climber-fiber-Purkinje innervation

abnormal cerebellar molecular layer ( J:204664 )

• decrease in the density of BDNF+ climbing fibers

• reduction of dense core vesicle density in the presynaptic area and a decrease in the number of synaptic vesicles per presynapse

abnormal synaptic bouton morphology ( J:204664 )

• reduction of dense core vesicle density in the presynaptic area

abnormal synaptic vesicle number ( J:204664 )

• reduction in the number of synaptic vesicles per presynapse

decreased excitatory postsynaptic current amplitude ( J:204664 )

• decrease in climbing fiber-EPSC amplitude

abnormal paired-pulse inhibition ( J:204664 )

• enhanced paired-pulse depression of climbing fiber EPSCs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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