All Phenotypes Cadps<tm1.2Tfr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cadps^tm1.2Tfr
targeted mutation 1.2, Teiichi Furuichi
MGI:5562542

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cadps^tm1.1Tfr/Cadps^tm1.2Tfr Emx1^tm1(cre)Ito/Emx1⁺	B6.Cg-Emx1^tm1(cre)Ito Cadps^tm1.1Tfr Cadps^tm1.2Tfr	MGI:5562543
cn2	Cadps^tm1.1Tfr/Cadps^tm1.2Tfr Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺	B6.Cg-Ptf1a^{tm1.1(cre)Cvw} Cadps^tm1.1Tfr Cadps^tm1.2Tfr	MGI:5562545

Allelic Composition	Cadps^tm1.1Tfr/Cadps^tm1.2Tfr Emx1^tm1(cre)Ito/Emx1⁺
Genetic Background	B6.Cg-Emx1^tm1(cre)Ito Cadps^tm1.1Tfr Cadps^tm1.2Tfr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadps^tm1.1Tfr mutation (1 available); any Cadps mutation (70 available)
Cadps^tm1.2Tfr mutation (0 available); any Cadps mutation (70 available)
Emx1^tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal Golgi trans cisterna morphology ( J:204664 )

• dilated Golgi cisternae on the trans side of the Golgi stack in hippocampal CA3 pyramidal neurons and dentate gyrus granule cells

nervous system

nervous system phenotype ( J:204664 )

N	• normal synaptic vesicle density and length of postsynaptic density in dentate gyrus granule cells

abnormal dentate gyrus morphology ( J:204664 )

• dilated Golgi cisternae on the trans side of the Golgi stack in dentate gyrus granule cells

• reduction of dense core vesicle density in the presynaptic terminal in dentate gyrus granule cells

abnormal hippocampus pyramidal cell morphology ( J:204664 )

• dilated Golgi cisternae on the trans side of the Golgi stack in hippocampal CA3 pyramidal neurons

abnormal synaptic bouton morphology ( J:204664 )

• reduction of dense core vesicle density in the presynaptic terminal in dentate gyrus granule cells

Allelic Composition	Cadps^tm1.1Tfr/Cadps^tm1.2Tfr Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺
Genetic Background	B6.Cg-Ptf1a^{tm1.1(cre)Cvw} Cadps^tm1.1Tfr Cadps^tm1.2Tfr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cadps^tm1.1Tfr mutation (1 available); any Cadps mutation (70 available)
Cadps^tm1.2Tfr mutation (0 available); any Cadps mutation (70 available)
Ptf1a^{tm1.1(cre)Cvw} mutation (1 available); any Ptf1a mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:204664 )

N	• normal basic synaptic transmission, short-term plasticity, and climber-fiber-Purkinje innervation

abnormal cerebellar molecular layer ( J:204664 )

• decrease in the density of BDNF+ climbing fibers

• reduction of dense core vesicle density in the presynaptic area and a decrease in the number of synaptic vesicles per presynapse

abnormal synaptic bouton morphology ( J:204664 )

• reduction of dense core vesicle density in the presynaptic area

abnormal synaptic vesicle number ( J:204664 )

• reduction in the number of synaptic vesicles per presynapse

decreased excitatory postsynaptic current amplitude ( J:204664 )

• decrease in climbing fiber-EPSC amplitude

abnormal paired-pulse inhibition ( J:204664 )

• enhanced paired-pulse depression of climbing fiber EPSCs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24