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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dab2tm2.1Xxx
targeted mutation 2.1, Xiang-Xi Xu
MGI:5562563
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dab2tm2.1Xxx/Dab2tm2.2Xxx
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA MGI:5562566
cn2
 		Dab2tm2.1Xxx/Dab2tm2.2Xxx
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J MGI:5562565


Genotype
MGI:5562566
cn1
Allelic
Composition		 Dab2tm2.1Xxx/Dab2tm2.2Xxx
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab2tm2.1Xxx mutation (0 available); any Dab2 mutation (53 available)
Dab2tm2.2Xxx mutation (0 available); any Dab2 mutation (53 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:205046 )
N
• viable

homeostasis/metabolism
increased circulating cholesterol level ( J:205046 )
• serum total cholesterol level is slightly but consistently increased

embryo
embryo phenotype ( J:205046 )
N
• no gross developmental defects




Genotype
MGI:5562565
cn2
Allelic
Composition		 Dab2tm2.1Xxx/Dab2tm2.2Xxx
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab2tm2.1Xxx mutation (0 available); any Dab2 mutation (53 available)
Dab2tm2.2Xxx mutation (0 available); any Dab2 mutation (53 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:205046 )
N
• viable, with about 10% of cells still expressing DAB2 protein




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory