All Phenotypes Dab2<tm2.2Xxx> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dab2^tm2.2Xxx
targeted mutation 2.2, Xiang-Xi Xu
MGI:5562564

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dab2^tm2.2Xxx/Dab2^tm2.2Xxx	involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	MGI:5562567
cn2	Dab2^tm2.1Xxx/Dab2^tm2.2Xxx Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA	MGI:5562566
cn3	Dab2^tm2.1Xxx/Dab2^tm2.2Xxx Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	MGI:5562565

Allelic Composition	Dab2^tm2.2Xxx/Dab2^tm2.2Xxx
Genetic Background	involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab2^tm2.2Xxx mutation (0 available); any Dab2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:205046 )

• no embryos survive to E9.5, appear to die around E5.5

• embryos in various states of degeneration are detected between E6.5 and E8.5

embryo

abnormal primitive endoderm morphology ( J:205046 )

• at E4.5, primitive endoderm cells are present but are not organized into a monolayer epithelium and some are located deep inside the inner cell mass

• at E5.5, endoderm cells are misplaced and intermixed within the egg cylinder core

disorganized extraembryonic tissue ( J:205046 )

• tissues derived from the primitive endoderm are disorganized at E5.5

Allelic Composition	Dab2^tm2.1Xxx/Dab2^tm2.2Xxx Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab2^tm2.1Xxx mutation (0 available); any Dab2 mutation (53 available)
Dab2^tm2.2Xxx mutation (0 available); any Dab2 mutation (53 available)
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:205046 )

• viable

homeostasis/metabolism

increased circulating cholesterol level ( J:205046 )

• serum total cholesterol level is slightly but consistently increased

increased circulating LDL cholesterol level ( J:205046 )

embryo

embryo phenotype ( J:205046 )

N	• no gross developmental defects

Allelic Composition	Dab2^tm2.1Xxx/Dab2^tm2.2Xxx Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab2^tm2.1Xxx mutation (0 available); any Dab2 mutation (53 available)
Dab2^tm2.2Xxx mutation (0 available); any Dab2 mutation (53 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:205046 )

N	• viable, with about 10% of cells still expressing DAB2 protein

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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