Phenotypes associated with this allele

• Allele Symbol: Cpeb3^tm1.2Yshu
• Allele Name: targeted mutation 1.2, Yi-Shuian Huang
• Allele ID: MGI:5562642
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpeb3^tm1.2Yshu/Cpeb3^tm1.2Yshu	involves: 129S4/SvJae * C57BL/6	MGI:5562644

Genotype
MGI:5562644

hm1

• Allelic Composition: Cpeb3^tm1.2Yshu/Cpeb3^tm1.2Yshu
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced female fertility ( J:202741 )

♂ • severely reduced

growth/size/body

growth/size/body region phenotype ( J:202741 )

♂N • normal body weight

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:202741 )

♂ • increase in Grin1-induced calcium influx in cultured neurons

vision/eye

vision/eye phenotype ( J:202741 )

♂N • normal visual acuity

behavior/neurological

behavior/neurological phenotype ( J:202741 )

♂N • normal motor coordination on the rotarod and locomotor abilities in the home-cage environment as well as normal spatial learning and swimming ability

enhanced contextual conditioning behavior ( J:202741 )

♂ • more rapid acquisition but slower extinction

abnormal spatial reference memory ( J:202741 )

♂ • better consolidated spatial memory in a Morris water maze

increased anxiety-related response ( J:202741 )

♂ • in open field but not in elevated plus maze

decreased locomotor activity ( J:202741 )

♂ • locomotor activity is significantly lower in the open field

nervous system

nervous system phenotype ( J:202741 )

♂N • normal paired-pulse facilitation in adult hippocampal slices

♂N • normal long term potentiation and long term depression in 9- to 12-week-old adult hippocampal slices

abnormal hippocampus pyramidal cell morphology ( J:202741 )

♂ • enlarge spine head at E18 with normal dendritic arborization

abnormal dendritic spine morphology ( J:202741 )

♂ • width of the spine heads of pyramidal excitatory neurons is enlarged at E18

abnormal neuron physiology ( J:202741 )

♂ • increase in Grin1-induced calcium influx in cultured neurons

abnormal long-term depression ( J:202741 )

♂ • paired-pulse low frequency stimulation induced LTD is enhanced in young (3-4 weeks of age) but not adult hippocampal slices