Phenotypes associated with this allele

• Allele Symbol: Mid1^tm1Aash
• Allele Name: targeted mutation 1, Alan Ashworth
• Allele ID: MGI:5562687
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mid1^tm1Aash/Mid1^tm1Aash	involves: 129	MGI:5562689

Genotype
MGI:5562689

hm1

• Allelic Composition: Mid1^tm1Aash/Mid1^tm1Aash
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal corpus callosum morphology ( J:202973 )

• callosal axons grow further into the contralateral hemisphere at P4

• at P14, axon distribution is disturbed with a greater number of axon terminals, with a wider distribution in both the S1 and S2 regions

• broader distribution of the contralateral axon projection pattern

abnormal axon morphology ( J:202973 )

• axon length and branch number are increased in cultured cortical neurons

• callosal axons grow further into the contralateral hemisphere at P4

• at P14, axon distribution in the corpus callosum is disturbed with a greater number of axon terminals, with a wider distribution in both the S1 and S2 regions

• broader distribution of the contralateral axon projection pattern in the corpus callosum

embryo

embryo phenotype ( J:202973 )

N • no obvious midline defects, unlike in Opitz Syndrome patients