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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rnf7tm1.1Ysun
targeted mutation 1.1, Yi Sun
MGI:5562909
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Krastm4Tyj/Kras+
Rnf7Gt(XE423)Byg/Rnf7tm1.1Ysun 		involves: 129P2/OlaHsd * 129S4/SvJae MGI:5562910


Genotype
MGI:5562910
cn1
Allelic
Composition		 Krastm4Tyj/Kras+
Rnf7Gt(XE423)Byg/Rnf7tm1.1Ysun
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Rnf7Gt(XE423)Byg mutation (0 available); any Rnf7 mutation (17 available)
Rnf7tm1.1Ysun mutation (0 available); any Rnf7 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:207982 )
• median survival time of Ad-Cre treated mice is 37.9 weeks, with most mice dying by 60 weeks

neoplasm
decreased lung tumor incidence ( J:207982 )
• mice show reduced lung tumor burden following intratracheal administration of an adenovirus expressing Cre (Ad-Cre) compared to single Kras homozygotes, however the number of hyperplastic loci is not affected
• hyperplasia or adenomas from Ad-Cre treated mice show reduced proliferation compared to single Kras homozygotes

respiratory system
decreased lung tumor incidence ( J:207982 )
• mice show reduced lung tumor burden following intratracheal administration of an adenovirus expressing Cre (Ad-Cre) compared to single Kras homozygotes, however the number of hyperplastic loci is not affected
• hyperplasia or adenomas from Ad-Cre treated mice show reduced proliferation compared to single Kras homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory