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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itchtm1.1Alta
targeted mutation 1.1, Alexander Tarakhovsky
MGI:5563090
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Itchtm1.1Alta/Itchtm1.1Alta
Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5563102
cn2
 		Itchtm1.1Alta/Itchtm1.1Alta
Foxp3tm4(YFP/icre)Ayr/Foxp3+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5563103


Genotype
MGI:5563102
cn1
Allelic
Composition		 Itchtm1.1Alta/Itchtm1.1Alta
Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sor+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (58 available)
Gt(ROSA)26Sortm1Hjf mutation (5 available); any Gt(ROSA)26Sor mutation (993 available)
Itchtm1.1Alta mutation (0 available); any Itch mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:204685 )
N
• regulatory T cells exhibit normal suppressive functions and stability




Genotype
MGI:5563103
cn2
Allelic
Composition		 Itchtm1.1Alta/Itchtm1.1Alta
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (58 available)
Itchtm1.1Alta mutation (0 available); any Itch mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:204685 )
• from 6 weeks of age

immune system
immune system phenotype ( J:204685 )
N
• mice exhibit normal response to experimental autoimmune encephalomyelitis
abnormal lymphopoiesis ( J:204685 )
• from 6 weeks of age, mice exhibit a lymphoproliferative disorder unlike wild-type mice
abnormal T-helper 2 cell differentiation ( J:204685 )
• increased when induced by regulatory T cells
• however, anti-IL4 antibody abolishes Th2 instruction
decreased CD4-positive, alpha-beta T cell number ( J:204685 )
• slightly decreased proportion in the spleen
increased leukocyte cell number ( J:204685 )
• in splenic red pulp
increased eosinophil cell number ( J:204685 )
• in the bronchoalveolar lavage fluid of ovalbumin-treated mice
increased IgA level ( J:204685 )
• modestly
increased IgE level ( J:204685 )
• ovalbumin-specific IgE in ovalbumin-treated mice
abnormal T-helper 2 physiology ( J:204685 )
• CD4+ T cells and anti-CD3-stimulated splenocytes produce more Th2 cytokines (IL4, IL5 and IL10) compared with wild-type mice
abnormal regulatory T cell physiology ( J:204685 )
• when injected into ovalbumin-immunized wild-type mice, regulatory T cells exacerbate Th2 immune responses in allergic reaction compared with wild-type cells
• however, regulatory T cells exhibit normal suppressive functions and stability
increased regulatory T cell apoptosis ( J:204685 )
• regulatory T cells exhibit increased resistance to activation-induced cell death compared with wild-type cells
abnormal lymph organ size ( J:204685 )
• from 6 weeks of age, mice exhibit larger size and cellularity of peripheral lymphoid organs compared with wild-type mice
increased interleukin-10 secretion ( J:204685 )
• from CD4+ T cells
• from anti-CD3-stimulated splenocytes
increased interleukin-13 secretion ( J:204685 )
• from anti-CD3-stimulated splenocytes
increased interleukin-17 secretion ( J:204685 )
• from CD4+ T cells in the lungs
increased interleukin-4 secretion ( J:204685 )
• from CD4+ T cells
• from anti-CD3-stimulated splenocytes
increased interleukin-5 secretion ( J:204685 )
• from CD4+ T cells
• from anti-CD3-stimulated splenocytes
increased inflammatory response ( J:204685 )
• massive infiltration in the lungs, stomach, skin and liver
• however, no lesions are observed in the kidney and colon
lung inflammation ( J:204685 )
• from 6 weeks of age
• more severe when induced by ovalbumin with increased total cells and eosinophils in the bronchoalveolar lavage fluid
dermatitis ( J:204685 )
• severe at 16 weeks

integument
dermatitis ( J:204685 )
• severe at 16 weeks
skin lesions ( J:204685 )
• from 6 weeks of age

respiratory system
lung inflammation ( J:204685 )
• from 6 weeks of age
• more severe when induced by ovalbumin with increased total cells and eosinophils in the bronchoalveolar lavage fluid

growth/size/body
weight loss ( J:204685 )
• from 6 weeks of age
enlarged spleen ( J:204685 )

cellular
increased regulatory T cell apoptosis ( J:204685 )
• regulatory T cells exhibit increased resistance to activation-induced cell death compared with wild-type cells

hematopoietic system
abnormal lymphopoiesis ( J:204685 )
• from 6 weeks of age, mice exhibit a lymphoproliferative disorder unlike wild-type mice
abnormal T-helper 2 cell differentiation ( J:204685 )
• increased when induced by regulatory T cells
• however, anti-IL4 antibody abolishes Th2 instruction
decreased CD4-positive, alpha-beta T cell number ( J:204685 )
• slightly decreased proportion in the spleen
increased leukocyte cell number ( J:204685 )
• in splenic red pulp
increased eosinophil cell number ( J:204685 )
• in the bronchoalveolar lavage fluid of ovalbumin-treated mice
increased IgA level ( J:204685 )
• modestly
increased IgE level ( J:204685 )
• ovalbumin-specific IgE in ovalbumin-treated mice
abnormal T-helper 2 physiology ( J:204685 )
• CD4+ T cells and anti-CD3-stimulated splenocytes produce more Th2 cytokines (IL4, IL5 and IL10) compared with wild-type mice
abnormal regulatory T cell physiology ( J:204685 )
• when injected into ovalbumin-immunized wild-type mice, regulatory T cells exacerbate Th2 immune responses in allergic reaction compared with wild-type cells
• however, regulatory T cells exhibit normal suppressive functions and stability
increased regulatory T cell apoptosis ( J:204685 )
• regulatory T cells exhibit increased resistance to activation-induced cell death compared with wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory