Phenotypes associated with this allele

• Allele Symbol: Stx1a^tm1Migar
• Allele Name: targeted mutation 1, Michihiro Igarashi
• Allele ID: MGI:5563140
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Stx1a^tm1Migar/Stx1a^+	involves: C57BL/6N	MGI:5563182

Genotype
MGI:5563182

ht1

• Allelic Composition: Stx1a^tm1Migar/Stx1a⁺
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:204968 )

N • basal synaptic transmission is normal

abnormal synaptic vesicle number ( J:204968 )

• mature mice exhibit reduced synaptic vesicle density compared with wild-type mice

• however, readily releasable pool size is normal

abnormal neuron physiology ( J:204968 )

• larger amplitude of depletion of synaptic vesicles in the readily reducible pool induced by high frequency stimulation

abnormal synaptic vesicle recycling ( J:204968 )

• impaired, delayed

impaired synaptic plasticity ( J:204968 )

• impaired short term plasticity

increased post-tetanic potentiation ( J:204968 )

decreased synaptic depression ( J:204968 )

• soon after stimulation

• smaller late phase depression

enhanced paired-pulse facilitation ( J:204968 )

behavior/neurological

impaired contextual conditioning behavior ( J:204968 )

• reduced freezing

abnormal spatial working memory ( J:204968 )

• impaired performance in the eight-arm radial maze

abnormal depression-related behavior ( J:204968 )

• in the Porsolt forced swim test, mice travel further and spend less time immobilized compared with wild-type mice

decreased anxiety-related response ( J:204968 )

• in an open field

increased locomotor activity ( J:204968 )

• in an open field