Phenotypes associated with this allele

• Allele Symbol: Tnfsf15^tm1Hluo
• Allele Name: targeted mutation 1, Hongyu Luo
• Allele ID: MGI:5563219
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfsf15^tm1Hluo/Tnfsf15^tm1Hluo	D1LacJ.129(B6)-Tnfsf15^tm1Hluo	MGI:5563220

Genotype
MGI:5563220

hm1

• Allelic Composition: Tnfsf15^tm1Hluo/Tnfsf15^tm1Hluo
• Genetic Background: D1LacJ.129(B6)-Tnfsf15^tm1Hluo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:207029 )

N • mice exhibit normal B cell, T cell, Th1, Th2, Th17 and regulatory T cell development, anti-LCMV immune responses and immunoglobulin levels

decreased B cell number ( J:207029 )

• in the draining lymph nodes of collagen-immunized mice

decreased germinal center B cell number ( J:207029 )

• in collagen-immunized mice

decreased plasma cell number ( J:207029 )

• fewer anti-collagen antibody-secreting plasma cells in collagen-immunized mice

decreased T cell number ( J:207029 )

• in the draining lymph nodes of collagen-immunized mice

decreased T follicular helper cell number ( J:207029 )

• in the draining lymph nodes of collagen-immunized mice

decreased IgG level ( J:207029 )

• collagen-specific antibody titers in collagen-immunized mice

decreased IgG2a level ( J:207029 )

• collagen-specific antibody titers in collagen-immunized mice

decreased IgG2b level ( J:207029 )

• collagen-specific antibody titers in collagen-immunized mice

lymph node hypoplasia ( J:207029 )

• smaller and hypoplastic draining lymph nodes in collagen-immunized mice

decreased susceptibility to induced arthritis ( J:207029 )

• collagen-immunized mice exhibit ameliorated arthritis development (smaller and hypoplastic draining lymph nodes, lower T and B cell numbers in draining lymph nodes and lower germinal center B cells) with slower onset, lower clinical scores compared and lower collagen-specific antibody titers with wild-type mice

skeleton

decreased susceptibility to induced arthritis ( J:207029 )

• collagen-immunized mice exhibit ameliorated arthritis development (smaller and hypoplastic draining lymph nodes, lower T and B cell numbers in draining lymph nodes and lower germinal center B cells) with slower onset, lower clinical scores compared and lower collagen-specific antibody titers with wild-type mice

hematopoietic system

decreased B cell number ( J:207029 )

• in the draining lymph nodes of collagen-immunized mice

decreased germinal center B cell number ( J:207029 )

• in collagen-immunized mice

decreased plasma cell number ( J:207029 )

• fewer anti-collagen antibody-secreting plasma cells in collagen-immunized mice

decreased T cell number ( J:207029 )

• in the draining lymph nodes of collagen-immunized mice

decreased T follicular helper cell number ( J:207029 )

• in the draining lymph nodes of collagen-immunized mice

decreased IgG level ( J:207029 )

• collagen-specific antibody titers in collagen-immunized mice

decreased IgG2a level ( J:207029 )

• collagen-specific antibody titers in collagen-immunized mice

decreased IgG2b level ( J:207029 )

• collagen-specific antibody titers in collagen-immunized mice