Phenotypes associated with this allele

• Allele Symbol: Cd72^tm1Tsub
• Allele Name: targeted mutation 1, Takeshi Tsubata
• Allele ID: MGI:5563226
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd72^tm1Tsub/Cd72^tm1Tsub	involves: C57BL/6J	MGI:5563350
cx2	Cd72^tm1Tsub/Cd72^tm1Tsub Fas^lpr/Fas^lpr	involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp	MGI:5563351

Genotype
MGI:5563350

hm1

• Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:204782 )

N • B cells exhibit normal calcium signaling

N • the proportion of T and B cells is normal

increased B cell proliferation ( J:204782 )

• in spleen B cells stimulated with CpG oligomers or anti-CD40 antibodies compared with cells from C57BL/6 mice

increased spleen weight ( J:204782 )

• mild

increased anti-chromatin antibody level ( J:204782 )

increased anti-double stranded DNA antibody level ( J:204782 )

increased anti-single stranded DNA antibody level ( J:204782 )

glomerulonephritis ( J:204782 )

• with immune complex deposition

lung inflammation ( J:204782 )

renal/urinary system

glomerulonephritis ( J:204782 )

• with immune complex deposition

renal glomerular immunoglobulin deposits ( J:204782 )

respiratory system

lung inflammation ( J:204782 )

hematopoietic system

increased B cell proliferation ( J:204782 )

• in spleen B cells stimulated with CpG oligomers or anti-CD40 antibodies compared with cells from C57BL/6 mice

increased spleen weight ( J:204782 )

• mild

growth/size/body

increased spleen weight ( J:204782 )

• mild

cellular

increased B cell proliferation ( J:204782 )

• in spleen B cells stimulated with CpG oligomers or anti-CD40 antibodies compared with cells from C57BL/6 mice

Genotype
MGI:5563351

cx2

• Allelic Composition: Cd72^tm1Tsub/Cd72^tm1Tsub; Fas^lpr/Fas^lpr
• Genetic Background: involves: C57BL/6J * C57BL/6JJmsSlc * MRL/Mp

immune system

increased spleen weight ( J:204782 )

• severe at 6 months

abnormal B cell number ( J:204782 )

• reduced percentage total B cells

abnormal T cell number ( J:204782 )

• marked increased percentage of lpr T cells in the spleen, lymph nodes and peritoneal cavity

• increased percentage of total T cells

enlarged lymph nodes ( J:204782 )

• severe at 6 months

autoimmune response ( J:204782 )

increased anti-chromatin antibody level ( J:204782 )

increased anti-double stranded DNA antibody level ( J:204782 )

• more so than in Cd72^tm1Tsub homozygotes

increased anti-single stranded DNA antibody level ( J:204782 )

• more so than in Cd72^tm1Tsub homozygotes

liver inflammation ( J:204782 )

• more so than in either single homozygotes

glomerulonephritis ( J:204782 )

• with immune complex deposition, more so than in either single homozygotes

lung inflammation ( J:204782 )

• more so than in either single homozygotes

renal/urinary system

glomerulonephritis ( J:204782 )

• with immune complex deposition, more so than in either single homozygotes

renal glomerular immunoglobulin deposits ( J:204782 )

liver/biliary system

liver inflammation ( J:204782 )

• more so than in either single homozygotes

respiratory system

lung inflammation ( J:204782 )

• more so than in either single homozygotes

hematopoietic system

increased spleen weight ( J:204782 )

• severe at 6 months

abnormal B cell number ( J:204782 )

• reduced percentage total B cells

abnormal T cell number ( J:204782 )

• increased percentage of total T cells

• marked increased percentage of lpr T cells in the spleen, lymph nodes and peritoneal cavity

growth/size/body

increased spleen weight ( J:204782 )

• severe at 6 months