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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp318m1Anu
mutation 1, Australian National University
MGI:5563395
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zfp318m1Anu/Zfp318m1Anu C57BL/6JAnu-Zfp318m1Anu MGI:5564983
ht2
 		Zfp318m1Anu/Zfp318+ C57BL/6JAnu-Zfp318m1Anu MGI:5578608


Genotype
MGI:5564983
hm1
Allelic
Composition		 Zfp318m1Anu/Zfp318m1Anu
Genetic
Background		 C57BL/6JAnu-Zfp318m1Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp318m1Anu mutation (1 available); any Zfp318 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell number ( J:104190 )
• slightly decreased the percentage of B cells
increased mature B cell number ( J:207375 )
• slight increase in proportion of mature recirculating B cells
abnormal follicular B cell physiology ( J:207375 )
• three-fold decreased IgD on follicular B cells
decreased IgD level ( J:104190 , J:207375 )
• abolished IgD expression on marginal zone B cells (J:104190)
• decreased IgD on follicular B cells (J:104190)
• absent on marginal zone B cells (J:207375)
• reduced on recirculating B cells in the bone marrow (J:207375)
• three-fold decrease on follicular B cells (J:207375)
increased IgM level ( J:104190 , J:207375 )
• on recirculating B cells in the bone marrow (J:207375)
abnormal marginal zone B cell physiology ( J:207375 )
• IgD expression is absent

hematopoietic system
hematopoietic system phenotype ( J:207375 )
N
• no significant difference in percentage of B cells or subset distribution of developing B cells
• normal frequencies of follicular B cells and marginal zone B cells
abnormal B cell number ( J:104190 )
• slightly decreased the percentage of B cells
increased mature B cell number ( J:207375 )
• slight increase in proportion of mature recirculating B cells
abnormal follicular B cell physiology ( J:207375 )
• three-fold decreased IgD on follicular B cells
decreased IgD level ( J:104190 , J:207375 )
• abolished IgD expression on marginal zone B cells (J:104190)
• decreased IgD on follicular B cells (J:104190)
• absent on marginal zone B cells (J:207375)
• reduced on recirculating B cells in the bone marrow (J:207375)
• three-fold decrease on follicular B cells (J:207375)
increased IgM level ( J:104190 , J:207375 )
• on recirculating B cells in the bone marrow (J:207375)
abnormal marginal zone B cell physiology ( J:207375 )
• IgD expression is absent

reproductive system




Genotype
MGI:5578608
ht2
Allelic
Composition		 Zfp318m1Anu/Zfp318+
Genetic
Background		 C57BL/6JAnu-Zfp318m1Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp318m1Anu mutation (1 available); any Zfp318 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgD level ( J:207375 )
• ~25% decrease
increased IgM level ( J:207375 )
• increased IgM on mature B cells

immune system
decreased IgD level ( J:207375 )
• ~25% decrease
increased IgM level ( J:207375 )
• increased IgM on mature B cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory