About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rbm5sda
spermatid differentiation arrest
MGI:5563424
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rbm5sda/Rbm5sda C57BL/6-Rbm5sda/MarpApb MGI:5564913
hm2
 		Rbm5sda/Rbm5sda involves: C57BL/6J * CBA MGI:5769990


Genotype
MGI:5564913
hm1
Allelic
Composition		 Rbm5sda/Rbm5sda
Genetic
Background		 C57BL/6-Rbm5sda/MarpApb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbm5sda mutation (2 available); any Rbm5 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatid morphology ( J:104190 )
• round spermatid arrest and spermatid differentiation arrest
abnormal male germ cell apoptosis ( J:104190 )
• germ cell sloughing and apoptosis
arrest of spermatogenesis ( J:104190 )
• round spermatid arrest and spermatid differentiation arrest

cellular
abnormal spermatid morphology ( J:104190 )
• round spermatid arrest and spermatid differentiation arrest
abnormal male germ cell apoptosis ( J:104190 )
• germ cell sloughing and apoptosis




Genotype
MGI:5769990
hm2
Allelic
Composition		 Rbm5sda/Rbm5sda
Genetic
Background		 involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbm5sda mutation (2 available); any Rbm5 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Spermatid differentiation arrest, germ cell sloughing and apoptosis lead to sterility in the Rbm5sda/Rbm5sda males

reproductive system
azoospermia ( J:223049 )
• no spermatozoa are found in adult epididymides
increased male germ cell apoptosis ( J:223049 )
• following arrest at step 8, germ cells are lost via sloughing as shown by the presence of immature germ cells within the epididymis
• at 8 weeks of age, the numbers of Caspase 3- and Caspase 9-positive cells per seminiferous tubule are significantly increased, indicating increased germ cell apoptosis
decreased testis weight ( J:223049 )
• ~50% reduction in testis weight at 8 weeks of age
testicular atrophy ( J:223049 )
• at 8 weeks of age
arrest of spermatogenesis ( J:223049 )
• spermatogenesis occurs up to step 8 of haploid germ cell development, after which germ cells are lost via both sloughing and apoptosis
arrest of spermiogenesis ( J:223049 )
• complete block of spermatid (haploid male germ cell) differentiation
• however, serum testosterone, FSH and LH levels are normal at 10-14 weeks of age
male infertility ( J:223049 )
• males are sterile at all ages examined (8 weeks to 6 months)
• Background Sensitivity: male sterility is uniform on both mixed C57BL/6J x CBA and congenic C57BL/6J genetic backgrounds

cellular
azoospermia ( J:223049 )
• no spermatozoa are found in adult epididymides
increased male germ cell apoptosis ( J:223049 )
• following arrest at step 8, germ cells are lost via sloughing as shown by the presence of immature germ cells within the epididymis
• at 8 weeks of age, the numbers of Caspase 3- and Caspase 9-positive cells per seminiferous tubule are significantly increased, indicating increased germ cell apoptosis

endocrine/exocrine glands
decreased testis weight ( J:223049 )
• ~50% reduction in testis weight at 8 weeks of age
testicular atrophy ( J:223049 )
• at 8 weeks of age

respiratory system
respiratory system phenotype ( J:223049 )
N
• contrary to expectation, both males and females show normal lung histology at 9 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory