Phenotypes associated with this allele

• Allele Symbol: Kl^m1Anu
• Allele Name: mutation 1, Australian National University
• Allele ID: MGI:5563457
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kl^m1Anu/Kl^m1Anu	C57BL/6NCrlAnu-Kl^m1Anu	MGI:5566505

Genotype
MGI:5566505

hm1

• Allelic Composition: Kl^m1Anu/Kl^m1Anu
• Genetic Background: C57BL/6NCrlAnu-Kl^m1Anu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney morphology ( J:104190 )

• bronze

abnormal kidney collecting duct morphology ( J:104190 )

• golden pigment

abnormal kidney cortex morphology ( J:104190 )

• severe mineralization that is multifocal to coalescing and involves the tubular tissues and blood vessel walls

abnormal kidney medulla morphology ( J:104190 )

• golden pigment in medullary tubules

hematopoietic system

abnormal definitive hematopoiesis ( J:104190 )

• minimal haemopoiesis is evident in the red pulp

abnormal spleen morphology ( J:104190 )

• complete absence of periarteriolar lymphoid sheaths

small spleen ( J:104190 )

• very small

respiratory system

abnormal tracheal cartilage morphology ( J:104190 )

• severe mineralisation of tracheal cartilage rings and submucosa

respiratory distress ( J:104190 )

muscle

diaphragmatic hernia ( J:104190 )

• loops of small intestine indicating the presence of a diaphragmatic hernia

abnormal smooth muscle morphology ( J:104190 )

• moderate mineralisation of the smooth muscle of the tunica muscularis

immune system

abnormal spleen morphology ( J:104190 )

• complete absence of periarteriolar lymphoid sheaths

small spleen ( J:104190 )

• very small

homeostasis/metabolism

increased circulating calcium level ( J:104190 )

dehydration ( J:104190 )

• moderate

digestive/alimentary system

abnormal duodenum morphology ( J:104190 )

• effaced lamina prioria due to large amounts of mineralization

abnormal stomach morphology ( J:104190 )

• severe dilatation of occasional gastric glands with necrotic cellular content as well as fragments of calcium

• severe mineralisation of all small blood vessels and the entire submucosa of the glandular stomach

dilated gastric gland ( J:104190 )

• severe dilatation of occasional gastric glands

cardiovascular system

abnormal heart morphology ( J:104190 )

• severe multifocal mineralisation of the aorta and large blood vessels

hemorrhage ( J:104190 )

• moderate medullary haemorrhage in the bone

skeleton

abnormal tracheal cartilage morphology ( J:104190 )

• severe mineralisation of tracheal cartilage rings and submucosa

absent bone trabeculae ( J:104190 )

• may be related to excessive bone destruction resulting in hypercalcaemia

limbs/digits/tail

abnormal autopod morphology ( J:104190 )

• small, focal areas of mineralisation in the dermal tissue, connective tissue and adjacent to the bone

endocrine/exocrine glands

dilated gastric gland ( J:104190 )

• severe dilatation of occasional gastric glands