Phenotypes associated with this allele

• Allele Symbol: Etv5^sco
• Allele Name: sco
• Allele ID: MGI:5563470
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etv5^sco/Etv5^sco	involves: C57BL/6JAnu * CBA	MGI:5564923

Genotype
MGI:5564923

hm1

• Allelic Composition: Etv5^sco/Etv5^sco
• Genetic Background: involves: C57BL/6JAnu * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Etv5^sco/Etv5^sco males are sterile due to the progressive loss of germ cells

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:208684 )

postnatal lethality, incomplete penetrance ( J:208684 )

reproductive system

decreased male germ cell number ( J:208684 )

♂ • by 5 weeks

♂ • pronounced at 7 weeks; lost in a basal to apical direction

azoospermia ( J:208684 )

♂ • at 8 weeks

small testis ( J:208684 )

♂ • at 8 weeks

decreased testis weight ( J:208684 )

♂ • at 8 weeks

female infertility ( J:208684 )

♀

male infertility ( J:208684 )

♂

renal/urinary system

abnormal kidney morphology ( J:208684 )

• renal asymmetry in 5 of 15 adult mice

growth/size/body

decreased body weight ( J:208684 )

• by 3 weeks

• at 3 months

limbs/digits/tail

polydactyly ( J:208684 )

• in 8 of 15 adult mice

endocrine/exocrine glands

small testis ( J:208684 )

♂ • at 8 weeks

decreased testis weight ( J:208684 )

♂ • at 8 weeks

cellular

decreased male germ cell number ( J:208684 )

♂ • by 5 weeks

♂ • pronounced at 7 weeks; lost in a basal to apical direction

azoospermia ( J:208684 )

♂ • at 8 weeks