Phenotypes associated with this allele

• Allele Symbol: Dzip1l^warpy
• Allele Name: warpy
• Allele ID: MGI:5563494
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dzip1l^warpy/Dzip1l^warpy	involves: C3H * C57BL/6	MGI:6107228
hm2	Dzip1l^warpy/Dzip1l^warpy	involves: C57BL/6 * CD-1	MGI:6107229

Genotype
MGI:6107228

hm1

• Allelic Composition: Dzip1l^warpy/Dzip1l^warpy
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

bilateral cleft upper lip ( J:249936 )

• bilateral cleft upper lip

cleft palate ( J:249936 )

digestive/alimentary system

cleft palate ( J:249936 )

growth/size/body

bilateral cleft upper lip ( J:249936 )

• bilateral cleft upper lip

cleft palate ( J:249936 )

kidney cyst ( J:249936 )

• from 15.5 dpc

limbs/digits/tail

polydactyly ( J:249936 )

• on all four limbs

mortality/aging

lethality, incomplete penetrance ( J:249936 )

• expected Mendelian frequency at mid-gestation (10.5 dpc) but decreased viability at later stages

prenatal lethality prior to heart atrial septation ( J:249936 )

• expected Mendelian frequency at mid-gestation (10.5 dpc) but decreased viability at later stages

renal/urinary system

kidney cyst ( J:249936 )

• from 15.5 dpc

vision/eye

abnormal eye morphology ( J:249936 )

• in 67% of embryos from 13.5 dpc

abnormal eye distance/ position ( J:249936 )

• sometimes internalized eyes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive polycystic kidney disease		DOID:0110861		J:249936

Genotype
MGI:6107229

hm2

• Allelic Composition: Dzip1l^warpy/Dzip1l^warpy
• Genetic Background: involves: C57BL/6 * CD-1

renal/urinary system

kidney cyst ( J:249936 )

• throughout kidney by P21

kidney cortex cyst ( J:249936 )

• at P0

kidney medulla cyst ( J:249936 )

• at P0

increased kidney weight ( J:249936 )

• at P21

dilated kidney collecting duct ( J:249936 )

• at P0

dilated proximal convoluted tubule ( J:249936 )

• at P0

liver/biliary system

bile duct proliferation ( J:249936 )

• at P21

endocrine/exocrine glands

bile duct proliferation ( J:249936 )

• at P21

growth/size/body

kidney cyst ( J:249936 )

• throughout kidney by P21

kidney cortex cyst ( J:249936 )

• at P0

kidney medulla cyst ( J:249936 )

• at P0

increased kidney weight ( J:249936 )

• at P21

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive polycystic kidney disease		DOID:0110861		J:249936