Phenotypes associated with this allele

• Allele Symbol: Fendrr^tm1Vlcg
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:5563522
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fendrr^tm1Vlcg/Fendrr^tm1Vlcg	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N	MGI:5563523
hm2	Fendrr^tm1Vlcg/Fendrr^tm1Vlcg	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5812368

Genotype
MGI:5563523

hm1

• Allelic Composition: Fendrr^tm1Vlcg/Fendrr^tm1Vlcg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:204277 )

• die within 24 h of birth

respiratory system

abnormal lung vasculature morphology ( J:204277 )

• decrease in the number and organization of pulmonary arteries at E14.5

• general failure of vasculogenesis in the lungs at E14.5

pulmonary hypoplasia ( J:204277 )

• at E14.5

abnormal pulmonary alveolus morphology ( J:204277 )

• appear to have fewer but larger alveoli at E18.5

respiratory failure ( J:204277 )

• mice delivered surgically at E18.5 either fail to breathe or gasp and stop breathing within 5 h

digestive/alimentary system

abnormal esophagus morphology ( J:204277 )

• thinning of the mesenchymal layer of the mucosa at E18.5

abnormal esophageal smooth muscle morphology ( J:204277 )

• thinning of the external smooth muscle layers at E18.5

cardiovascular system

abnormal lung vasculature morphology ( J:204277 )

• decrease in the number and organization of pulmonary arteries at E14.5

• general failure of vasculogenesis in the lungs at E14.5

ventricular septal defect ( J:204277 )

• at E18.5

muscle

abnormal esophageal smooth muscle morphology ( J:204277 )

• thinning of the external smooth muscle layers at E18.5

Genotype
MGI:5812368

hm2

• Allelic Composition: Fendrr^tm1Vlcg/Fendrr^tm1Vlcg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Abnormal, disorganized, globular phenotype in the lobes of E13.5 Fendrr^tm1Vlcg/Fendrr^tm1Vlcg lungs

mortality/aging

neonatal lethality, complete penetrance ( J:233815 )

• mice survive to birth but succumb shortly thereafter due to breathing problems

respiratory system

abnormal lung development ( J:233815 )

• mice exhibit defective structural maturation of the lungs

abnormal lung lobe morphology ( J:233815 )

• at E13.5, lungs lobes appear globular and disorganized

small lung ( J:233815 )

• at E13.5, lungs are smaller than normal

respiratory distress ( J:233815 )

• neonates die from apparent respiratory distress