Phenotypes associated with this allele

• Allele Symbol: Pantr2^tm1Vlcg
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:5563531
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pantr2^tm1Vlcg/Pantr2^tm1Vlcg	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N	MGI:5563548

Genotype
MGI:5563548

hm1

• Allelic Composition: Pantr2^tm1Vlcg/Pantr2^tm1Vlcg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased neocortex size ( J:204277 )

• decrease in the total thickness of the neocortex at P7

• distinct decrease in the thickness in the upper layer II/III-IV at P7

abnormal barrel cortex morphology ( J:204277 )

• decrease in the total size of the barrel cortex with a more pronounced loss of Rorb+ neurons at the medial age

• decrease in overall area and number of barrels in the posteriomedial barrel subfield

disorganized barrel cortex ( J:204277 )

• disruption of individual barrel structures particularly within the anteriolateral barrel subfield

abnormal embryonic/fetal subventricular zone morphology ( J:204277 )

• decrease in the number of pH3+ intermediate progenitor cells in the subventricular zone at E15.5

• however, no change in the proliferation rate of apical progenitors is detected in the ventricular zone

decreased neuron number ( J:204277 )

• decrease in the number of callosal projection neurons in the cortex

increased neuron number ( J:204277 )

• increase in the number of subcerebral projection neurons and corticothalamic projection neurons in the cortex

growth/size/body

decreased body weight ( J:204277 )

• noticeable at 3 weeks of age