Analysis Tools|
Allele Symbol Allele Name Allele ID |
Lncpinttm1Vlcg targeted mutation 1, Velocigene MGI:5563545 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• noticeable at 3 weeks of age
• at 7 weeks of age females and males have a 22% and 29% reduction in body weight compared to sex-matched controls, respectively
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Skin abnormalities and lordokyphosis in Lncpinttm1Vlcg/Lncpinttm1Vlcg mice
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• males exhibit a significant reduction in survival relative to heterozygous and wild-type controls over a 1-year observation period
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• mice begin showing signs of early onset aging-like phenotypes at 3 months of age
• however, no signs of tumors or lesions are observed with increasing aging
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• males show a significantly lower total body fat mass than wild-type controls as early as 26 weeks of age
• females exhibit reduced body fat mass at 52 weeks of age, i.e. later than males
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• males show significantly decreased lean mass at 52 weeks of age
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• by one year of age, males are more than 30% lighter than wild-type males, whereas females are 27% lighter than wild-type females
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• some mice develop herniation, such as protrusion of the xiphoid process on the chest along with thinning of the abdominal wall
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• although both male and females show a significantly slower growth rate than wild-type controls, this is more pronounced in males
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• mice show variable but age-dependent hindlimb clasping when suspended by the tail, suggesting a progressive decline in muscle strength
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• mice show a severe reduction in the thickness of the subcutaneous fat layer as they age
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• ventral and dorsal skin sections indicate significant fibrosis
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• mice show a severe reduction in the thickness of the subcutaneous fat layer as they age
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• males show a significantly lower total body fat mass than wild-type controls as early as 26 weeks of age
• females exhibit reduced body fat mass at 52 weeks of age, i.e. later than males
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• starting at 26 weeks of age
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• starting at 26 weeks of age
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• both males and females show significantly reduced muscle mass for the gastrocnemius complex and tibialis anterior starting at 26 weeks of age
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• some mice exhibit protrusion of the xiphoid process on the chest along with thinning of the abdominal wall
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• ~70% (6/9 males and 7/10 females) of mice exhibit lordokyphosis at 12 weeks of age, and this frequency increases to ~90% (7/8 males and 8/9 females) by 26 weeks of age
• ~95% of mice (9/9 including those that died before the 52 week time-point, or 6/6 surviving males and 8/9 surviving females) display lordokyphosis by 52 weeks of age; in contrast, less than 20% (2/10 males and 2/11 females) of wild-type controls show mild lordokyphosis at 26 weeks of age, and this frequency does not increase with age
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• mice show significantly lower femur bone mineral density than wild-type controls as they age
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• starting at 26 weeks of age
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• starting at 26 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• males show a significantly lower total body fat mass than wild-type controls as early as 26 weeks of age
• females exhibit reduced body fat mass at 52 weeks of age, i.e. later than males
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• by one year of age, males are 15% lighter than wild-type males
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• males exhibit a significantly slower growth rate than wild-type controls
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• males show a significantly lower total body fat mass than wild-type controls as early as 26 weeks of age
• females exhibit reduced body fat mass at 52 weeks of age, i.e. later than males
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• less than 20% of mice (1/12 males and 2/10 females) show lordokyphosis at 12 weeks of age, and this frequency increases to ~60% (8/12 males and 6/10 females) by 26 weeks of age, relative to less than 20% (2/10 males and 2/11 females) of age-matched wild-type controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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