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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mylktm1.1Bph
targeted mutation 1.1, B Paul Herring
MGI:5563563
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mylktm1.1Bph/Mylktm1.1Bph involves: C57BL/6N MGI:5563579
cn2
 		Mylktm1.1Bph/Mylktm1.1Bph
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: C57BL/6 * C57BL/6N * DBA/2 MGI:5563580
cn3
 		Mylktm1.1Bph/Mylktm1.2Bph
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: C57BL/6 * C57BL/6N * DBA/2 MGI:5563581


Genotype
MGI:5563579
hm1
Allelic
Composition		 Mylktm1.1Bph/Mylktm1.1Bph
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mylktm1.1Bph mutation (0 available); any Mylk mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:204964 )
• mice reach adulthood without any obvious growth and behavioral abnormalities




Genotype
MGI:5563580
cn2
Allelic
Composition		 Mylktm1.1Bph/Mylktm1.1Bph
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mylktm1.1Bph mutation (0 available); any Mylk mutation (103 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Shorter small intestines in mgi:5563563/mgi:5563563 mgi:2653286/0 and mgi:5563563/mgi:5563564 mgi:2653286/0 mice

mortality/aging
neonatal lethality, incomplete penetrance ( J:204964 )
• fewer than expected mice are born
prenatal lethality, incomplete penetrance ( J:204964 )
• fewer than expected mice are born

digestive/alimentary system
abnormal small intestine morphology ( J:204964 )
• shorter than in control mice

muscle
impaired smooth muscle contractility ( J:204964 )
• induced by high KCl, carbachol or ET1 in the colon
• however, the L-type calcium channel inhibitor diltiazem blocks contractile responses to high KCl

growth/size/body
growth/size/body region phenotype ( J:204964 )
N
• mice exhibit normal body weight




Genotype
MGI:5563581
cn3
Allelic
Composition		 Mylktm1.1Bph/Mylktm1.2Bph
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mylktm1.1Bph mutation (0 available); any Mylk mutation (103 available)
Mylktm1.2Bph mutation (0 available); any Mylk mutation (103 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Shorter small intestines in mgi:5563563/mgi:5563563 mgi:2653286/0 and mgi:5563563/mgi:5563564 mgi:2653286/0 mice

mortality/aging
neonatal lethality, incomplete penetrance ( J:204964 )
• fewer than expected mice are born
prenatal lethality, incomplete penetrance ( J:204964 )
• fewer than expected mice are born

digestive/alimentary system
abnormal small intestine morphology ( J:204964 )
• shorter than in control mice

muscle
impaired smooth muscle contractility ( J:204964 )
• induced by high KCl, carbachol or ET1 in the colon
• however, the L-type calcium channel inhibitor diltiazem blocks contractile responses to high KCl

growth/size/body
growth/size/body region phenotype ( J:204964 )
N
• mice exhibit normal body weight




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory