Phenotypes associated with this allele

• Allele Symbol: Tg(Gt(ROSA)26Sor-Ndufa5)#Ctm
• Allele Name: transgene insertion, Carlos T Moraes
• Allele ID: MGI:5563661
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ndufa5^Gt(RRK279)Byg/Ndufa5^Gt(RRK279)Byg Tg(Camk2a-cre)#Szi/0 Tg(Gt(ROSA)26Sor-Ndufa5)#Ctm/0	involves: 129P2/OlaHsd * C57BL/6J * CBA * SJL	MGI:5563770

Genotype
MGI:5563770

cn1

• Allelic Composition: Ndufa5^{Gt(RRK279)Byg}/Ndufa5^{Gt(RRK279)Byg}; Tg(Camk2a-cre)#Szi/0; Tg(Gt(ROSA)26Sor-Ndufa5)#Ctm/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

lethargy ( J:206222 )

• at 10 to 11 months

limb grasping ( J:206222 )

• at 10 to 11 months

impaired coordination ( J:206222 )

• at 10 to 11 months, mice exhibit longer latency in a pole descent test and reduced motor coordination in the grid and beam-walking tests compared with control mice

cellular

abnormal respiratory electron transport chain ( J:206222 )

• mice exhibit complex I deficiency in the cortex compared with wild-type mice

nervous system

nervous system phenotype ( J:206222 )

N • at 11 months, cortex morphology is normal without oxidative damage