mortality/aging
• fewer than expected mice are present at weaning
|
skeleton
N |
• chondrocyte proliferation is normal
• cortical bones exhibit normal morphology
|
• at E16.5
|
• at E14.5, E16.5 and E18.5
• in adult mice
|
short ulna
(
J:205339
)
• at E14.5, E16.5 and E18.5
• in adult mice
|
short ribs
(
J:205339
)
• short and thick
|
• in adult mice
|
• decreased radius of the endosteal and periosteal radius
|
• more rapidly maturing chondrocytes compared with wild-type mice
|
• decreased radius
|
• with increased spacing
|
• in prehypertrophic and hypertrophic domains
|
• suggested by reduced skeletal element length
|
• of the talus at E18.5 and cervical vertebrae at E16.5
|
growth/size/body
N |
• crown to rump length at E16.5 is normal
|
short snout
(
J:205339
)
craniofacial
• at E16.5
|
short snout
(
J:205339
)
cellular
• more rapidly maturing chondrocytes compared with wild-type mice
|
immune system
• more rapidly maturing chondrocytes compared with wild-type mice
|
limbs/digits/tail
• short at E14.5 and E16.5
|
• at E14.5, E16.5 and E18.5
• in adult mice
|
• short at E14.5 and E16.5
|
short ulna
(
J:205339
)
• at E14.5, E16.5 and E18.5
• in adult mice
|
• short at E14.5 and E16.5
|
• short at E14.5 and E16.5
|
• at E18.5 and worse in adulthood
• rhizomelic shortening in adult mice
|
hematopoietic system
• more rapidly maturing chondrocytes compared with wild-type mice
|