All Phenotypes Alox15<tm1.2Nadl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Alox15^tm1.2Nadl
targeted mutation 1.2, Jerry Nadler
MGI:5563793

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alox15^tm1.2Nadl/Alox15^tm1.2Nadl	involves: C57BL/6	MGI:5563800

Allelic Composition	Alox15^tm1.2Nadl/Alox15^tm1.2Nadl
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alox15^tm1.2Nadl mutation (0 available); any Alox15 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:207723 )

N	• mice exhibit normal basal blood pressure

abnormal systemic arterial blood pressure ( J:207723 )

• L-NAME-treated mice fail to exhibit an increase in blood pressure unlike wild-type mice

• however, adoptive transfer of elicited mutant macrophage into mutant hosts rescues response to L-NAME

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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