All Phenotypes Mir128-2<tm1.1Ans> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mir128-2^tm1.1Ans
targeted mutation 1.1, Anne Schaefer
MGI:5563796

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Camk2a-cre)2Gsc/0	involves: BALB/cJ * C57BL/6J * FVB/N	MGI:5563802
cn2	Gt(ROSA)26Sor^{tm2(CAG-Mir128-2)Ans}/Gt(ROSA)26Sor⁺ Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Camk2a-cre)2Gsc/0	involves: BALB/cJ * C57BL/6J * FVB/N	MGI:5563803
cn3	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Drd1-cre)EY262Gsat/0	involves: BALB/cJ * C57BL/6J * FVB/N	MGI:5563804
cn4	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Adora2a-cre)KG139Gsat/0	involves: BALB/cJ * C57BL/6J * FVB/N	MGI:5563805

Allelic Composition	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Camk2a-cre)2Gsc/0
Genetic Background	involves: BALB/cJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir128-2^tm1.1Ans mutation (0 available); any Mir128-2 mutation (0 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:205260 )

• die at 2 to 3 months of age, similar to germ line null mice

behavior/neurological

hyperactivity ( J:205260 )

• early onset

increased vertical activity ( J:205260 )

seizures ( J:205260 )

nervous system

seizures ( J:205260 )

Allelic Composition	Gt(ROSA)26Sor^{tm2(CAG-Mir128-2)Ans}/Gt(ROSA)26Sor⁺ Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Camk2a-cre)2Gsc/0
Genetic Background	involves: BALB/cJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(CAG-Mir128-2)Ans} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Mir128-2^tm1.1Ans mutation (0 available); any Mir128-2 mutation (0 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:205260 )

• viable with normal locomotor activity levels

Allelic Composition	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Drd1-cre)EY262Gsat/0
Genetic Background	involves: BALB/cJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir128-2^tm1.1Ans mutation (0 available); any Mir128-2 mutation (0 available)
Tg(Drd1-cre)EY262Gsat mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:205260 )

• at about 5 months of age

behavior/neurological

hyperactivity ( J:205260 )

• juvenile

• administration of a MAP2K1 specific inhibitor SL327 normalizes locomotor activity

increased vertical activity ( J:205260 )

seizures ( J:205260 )

nervous system

seizures ( J:205260 )

increased dendritic spine number ( J:205260 )

• about a 20% increase in functional dendritic spines in striatal slices

abnormal action potential ( J:205260 )

• enhanced dendritic excitability in striatal slices

Allelic Composition	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Adora2a-cre)KG139Gsat/0
Genetic Background	involves: BALB/cJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir128-2^tm1.1Ans mutation (0 available); any Mir128-2 mutation (0 available)
Tg(Adora2a-cre)KG139Gsat mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:205260 )

• viable with normal locomotor activity levels

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