Phenotypes associated with this allele

• Allele Symbol: Crb3^tm1.2Bmar
• Allele Name: targeted mutation 1.2, Ben Margolis
• Allele ID: MGI:5563835
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crb3^tm1.2Bmar/Crb3^tm1.2Bmar	B6.129(Cg)-Crb3^tm1.2Bmar	MGI:5563904

Genotype
MGI:5563904

hm1

• Allelic Composition: Crb3^tm1.2Bmar/Crb3^tm1.2Bmar
• Genetic Background: B6.129(Cg)-Crb3^tm1.2Bmar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:206750 )

• mice die within 10 minutes of birth due to respiratory distress

respiratory system

abnormal respiratory motile cilium morphology ( J:206750 )

• membrane blebs interrupts the arrangement of motile cilia in the lungs and membrane protrusions in the cell lining the bronchioles

abnormal lung morphology ( J:206750 )

• lung membrane blebs filled with proteinaceous material at E18.5

• membrane blebs interrupts the arrangement of motile cilia in the lungs and membrane protrusions in the cell lining the bronchioles

abnormal club cell morphology ( J:206750 )

• blebs

abnormal pulmonary alveolus morphology ( J:206750 )

• debris fills the airways with alveolar macrophages and eosinophilic fibrillar material

• decreased air space expansion

• focal proteinosis debris

• however, mice exhibit normal number of proximal airways and sacculations per section

increased pulmonary alveolus wall thickness ( J:206750 )

• alveolar walls appear thickened and hypercellular

respiratory distress ( J:206750 )

digestive/alimentary system

abnormal intestine morphology ( J:206750 )

• gut lumen appears filled with debris perinatally unlike in wild-type mice

abnormal small intestinal villus morphology ( J:206750 )

• rough topology

abnormal small intestinal microvillus morphology ( J:206750 )

decreased small intestinal microvillus size ( J:206750 )

• perinatally

fused small intestinal villi ( J:206750 )

• fusion in the duodenum at E15.5 and E17.5

• fusion in the jejunum at E17.5

renal/urinary system

kidney cyst ( J:206750 )

• at E18.5

abnormal proximal convoluted tubule brush border morphology ( J:206750 )

• abnormal with partial loss in some tubules

dilated renal tubule ( J:206750 )

cellular

abnormal respiratory motile cilium morphology ( J:206750 )

• membrane blebs interrupts the arrangement of motile cilia in the lungs and membrane protrusions in the cell lining the bronchioles

growth/size/body

kidney cyst ( J:206750 )

• at E18.5