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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kmt2btm1Jjdh
targeted mutation 1.1, James J Hsieh
MGI:5565082
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kmt2btm1Jjdh/Kmt2btm1Jjdh Not Specified MGI:5565083
cx2
 		Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh
Kmt2btm1Jjdh/Kmt2btm1Jjdh 		involves: 129X1/SvJ MGI:5565088


Genotype
MGI:5565083
hm1
Allelic
Composition		 Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2btm1Jjdh mutation (0 available); any Kmt2b mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:112159 )
N
• no significant defect in proliferation of MEFs is detected




Genotype
MGI:5565088
cx2
Allelic
Composition		 Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh
Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1.1Jjdh mutation (0 available); any Kmt2a mutation (135 available)
Kmt2btm1Jjdh mutation (0 available); any Kmt2b mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased fibroblast proliferation ( J:112159 )
• in MEFs, decrease is more severe than in Kmt2atm1.1Jjdh single homozygotes

reproductive system
reproductive system phenotype ( J:205038 )
N
• males are fertile with normal testes morphology




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory