mortality/aging
• partial penetrance of lethality (65% penetrance) occurring within 2 weeks of birth
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growth/size/body
• at 1 week of age, females and males are 60% and 32% smaller than their sex-matched littermates, respectively
• at 10 weeks of age females are 37% smaller than sex-matched littermates
• difference in weight persists up to at least 8 weeks of age in males
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• severe
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