Phenotypes associated with this allele

• Allele Symbol: Ube3c^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5565262
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ube3c^tm1b(EUCOMM)Hmgu/Ube3c^tm1b(EUCOMM)Hmgu	C57BL/6NCrl-Ube3c^tm1b(EUCOMM)Hmgu/Rbrc	MGI:7415146
hm2	Ube3c^tm1b(EUCOMM)Hmgu/Ube3c^tm1b(EUCOMM)Hmgu	C57BL/6N-Ube3c^tm1b(EUCOMM)Hmgu/Rbrc	MGI:5757849

Genotype
MGI:7415146

hm1

• Allelic Composition: Ube3c^{tm1b(EUCOMM)Hmgu}/Ube3c^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6NCrl-Ube3c^{tm1b(EUCOMM)Hmgu}/Rbrc
• Cell Lines: HEPD0714_7_B01

Data Sources

IMPC Data for Ube3c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - HMGU

decreased vertical activity ( J:211773 )

IMPC - HMGU

decreased locomotor activity ( J:211773 )

♂

IMPC - HMGU

cardiovascular system

abnormal heart left ventricle morphology ( J:211773 )

♀

IMPC - HMGU

increased cardiac muscle contractility ( J:211773 )

♀

IMPC - HMGU

increased heart rate ( J:211773 )

IMPC - HMGU

growth/size/body

decreased body length ( J:211773 )

IMPC - HMGU

hematopoietic system

decreased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - HMGU

decreased CD5-positive Ly6C-positive T cell number ( J:211773 )

IMPC - HMGU

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - HMGU

decreased CD4-negative NK T cell number ( J:211773 )

♀

IMPC - HMGU

decreased Ly6C-positive NK T cell number ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

IMPC - HMGU

decreased circulating iron level ( J:211773 )

♀

IMPC - HMGU

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - HMGU

immune system

immune system phenotype ( J:211773 )

IMPC - HMGU

decreased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - HMGU

decreased CD5-positive Ly6C-positive T cell number ( J:211773 )

IMPC - HMGU

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - HMGU

decreased CD4-negative NK T cell number ( J:211773 )

♀

IMPC - HMGU

decreased Ly6C-positive NK T cell number ( J:211773 )

IMPC - HMGU

muscle

increased cardiac muscle contractility ( J:211773 )

♀

IMPC - HMGU

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - HMGU

vision/eye

decreased total retina thickness ( J:211773 )

IMPC - HMGU

Genotype
MGI:5757849

hm2

• Allelic Composition: Ube3c^{tm1b(EUCOMM)Hmgu}/Ube3c^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ube3c^{tm1b(EUCOMM)Hmgu}/Rbrc
• Cell Lines: HEPD0714_7_B01

Data Sources

IMPC Data for Ube3c

adipose tissue

increased total body fat amount ( J:211773 )

♀

IMPC - RBRC

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - RBRC

abnormal gait ( J:211773 )

♀

IMPC - RBRC

cardiovascular system

decreased heart weight ( J:211773 )

♂

IMPC - RBRC

growth/size/body

decreased body length ( J:211773 )

♀

IMPC - RBRC

hematopoietic system

increased leukocyte cell number ( J:211773 )

♂

IMPC - RBRC

increased lymphocyte cell number ( J:211773 )

♂

IMPC - RBRC

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - RBRC

increased circulating lactate dehydrogenase level ( J:211773 )

♂

IMPC - RBRC

decreased circulating serum albumin level ( J:211773 )

IMPC - RBRC

decreased respiratory quotient ( J:211773 )

IMPC - RBRC

immune system

increased leukocyte cell number ( J:211773 )

♂

IMPC - RBRC

increased lymphocyte cell number ( J:211773 )

♂

IMPC - RBRC

limbs/digits/tail

short tibia ( J:211773 )

♀

IMPC - RBRC

skeleton

short tibia ( J:211773 )

♀

IMPC - RBRC

decreased bone mineral content ( J:211773 )

IMPC - RBRC

decreased bone mineral density ( J:211773 )

IMPC - RBRC