All Phenotypes Grp<tm1Jfb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grp^tm1Jfb
targeted mutation 1, James F Battey
MGI:5565455

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grp^tm1Jfb/Grp^tm1Jfb	involves: 129X1/SvJ	MGI:6111350
cn2	Braf^tm1Cpri/Braf⁺ Grp^tm1Jfb/Grp^tm1Jfb Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129 * 129P2/OlaHsd * 129X1/SvJ * C57BL/6J	MGI:5565456
cx3	Grp^tm1Jfb/Grp^tm1Jfb Nmb^tm1Zfc/Nmb^tm1Zfc	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J	MGI:6111348

Allelic Composition	Grp^tm1Jfb/Grp^tm1Jfb
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grp^tm1Jfb mutation (1 available); any Grp mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal grooming behavior ( J:253572 )

• attenuated scratching in response to chloroquine, SLIGRL and BAM8-22 application

• however, application of histamine, compound 48/80 and 5-HT resulted in normal scratching behavior

Allelic Composition	Braf^tm1Cpri/Braf⁺ Grp^tm1Jfb/Grp^tm1Jfb Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braf^tm1Cpri mutation (0 available); any Braf mutation (60 available)
Grp^tm1Jfb mutation (1 available); any Grp mutation (30 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:205122 )

N	• spontaneous scratching, seen in mutant mice wild-type for Grp, is markedly diminished

Allelic Composition	Grp^tm1Jfb/Grp^tm1Jfb Nmb^tm1Zfc/Nmb^tm1Zfc
Genetic Background	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grp^tm1Jfb mutation (1 available); any Grp mutation (30 available)
Nmb^tm1Zfc mutation (0 available); any Nmb mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:253572 )

N	• mice exhibit normal pain behaviors

abnormal grooming behavior ( J:253572 )

• attenuated scratching in response to histamine, compound 48/80, 5-HT, chloroquine, SLIGRL and BAM8-22 application

nervous system

nervous system phenotype ( J:253572 )

N	• mice exhibit normal primary afferent projections

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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