Phenotypes associated with this allele

• Allele Symbol: Mtch2^tm1Atgr
• Allele Name: targeted mutation 1, Atan Gross
• Allele ID: MGI:5566663
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtch2^tm1Atgr/Mtch2^tm1Atgr	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:5566666

Genotype
MGI:5566666

hm1

• Allelic Composition: Mtch2^tm1Atgr/Mtch2^tm1Atgr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:209127 )

embryo

abnormal embryo development ( J:209127 )

• at E7.5, mutant embryos are significantly smaller in size and rounder in shape

abnormal gastrulation ( J:209127 )

• mutant embryos lack structures that are typical of gastrulation

abnormal mesoderm development ( J:209127 )

• diffuse and mislocalized expression of brachyury at E7.5

decreased embryo size ( J:209127 )

• 3-fold reduction of cell number in E7.5 embryos

absent mesoderm ( J:209127 )

• mesoderm is hardly detectable at E7.5

absent amnion ( J:209127 )

absent chorion ( J:209127 )

disorganized extraembryonic tissue ( J:209127 )

• no formal organization of the extraembryonic region is observed at E7.5

• only one large cavity is detected

growth/size/body

decreased embryo size ( J:209127 )

• 3-fold reduction of cell number in E7.5 embryos