Phenotypes associated with this allele

• Allele Symbol: Crtc2^tm1Mmy
• Allele Name: targeted mutation 1, Marc R Montminy
• Allele ID: MGI:5566704
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crtc2^tm1Mmy/Crtc2^tm1Mmy	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5566774

Genotype
MGI:5566774

hm1

• Allelic Composition: Crtc2^tm1Mmy/Crtc2^tm1Mmy
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased fasting circulating glucose level ( J:157556 )

• lower fasting blood glucose concentrations on a normal diet

decreased circulating insulin level ( J:157556 )

impaired gluconeogenesis ( J:157556 )

• reduced gluconeogenic capacity, as measured by pyruvate tolerance testing

• reduced glucose output from primary hepatocytes following exposure to glucagon

decreased hepatic glucose production ( J:157556 )

• reduced glucose output from primary hepatocytes following exposure to glucagon

increased insulin sensitivity ( J:157556 )

• increased whole body insulin sensitivity

• remain insulin sensitive on a high fat diet