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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aicdatm1.1Fwa
targeted mutation 1.1, Frederick W Alt
MGI:5566773
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aicdatm1.1Fwa/Aicdatm1.1Fwa involves: 129S6/SvEvTac MGI:5566787
ht2
 		Aicdatm1Hon/Aicdatm1.1Fwa involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj MGI:5566788


Genotype
MGI:5566787
hm1
Allelic
Composition		 Aicdatm1.1Fwa/Aicdatm1.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1.1Fwa mutation (0 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:209271 )
N
• mice exhibit normal numbers of splenic B and T cells and response to activation
abnormal class switch recombination ( J:209271 )
• decreased class switch recombination to IgG1 and IgG3
abnormal somatic hypermutation frequency ( J:209271 )
• reduced in Peyer's patch B cell

hematopoietic system
abnormal class switch recombination ( J:209271 )
• decreased class switch recombination to IgG1 and IgG3
abnormal somatic hypermutation frequency ( J:209271 )
• reduced in Peyer's patch B cell




Genotype
MGI:5566788
ht2
Allelic
Composition		 Aicdatm1Hon/Aicdatm1.1Fwa
Genetic
Background		 involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1.1Fwa mutation (0 available); any Aicda mutation (57 available)
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:209271 )
N
• mice exhibit normal numbers of splenic B and T cells and response to activation
abnormal class switch recombination ( J:209271 )
• severely decreased class switch recombination to IgG1 and IgG3

hematopoietic system
abnormal class switch recombination ( J:209271 )
• severely decreased class switch recombination to IgG1 and IgG3




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory