Phenotypes associated with this allele

• Allele Symbol: Gcgr^tm2.1Mjch
• Allele Name: targeted mutation 2.1, M J Charron
• Allele ID: MGI:5566811
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: C57BL/6 * DBA * SJL	MGI:5566824

Genotype
MGI:5566824

cn1

• Allelic Composition: Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: C57BL/6 * DBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased pancreatic alpha cell proliferation ( J:208604 )

• increased alpha-cell proliferation

homeostasis/metabolism

abnormal glucose homeostasis ( J:208604 )

• abrogated hyperglycemic response to acute glucagon challenge

decreased circulating glucose level ( J:208604 )

• in fasted and random samples

hypoglycemia ( J:208604 )

• mild

increased circulating glucagon level ( J:208604 )

decreased circulating insulin level ( J:208604 )

• in fasted mice

improved glucose tolerance ( J:208604 )

increased insulin sensitivity ( J:208604 )

increased bile salt level ( J:208604 )

• of total levels in plasma

endocrine/exocrine glands

increased pancreatic alpha cell proliferation ( J:208604 )

• increased alpha-cell proliferation

increased pancreatic alpha cell number ( J:208604 )

• alpha-cell hyperplasia

increased pancreatic beta cell mass ( J:208604 )

• increased beta-cell mass is secondary to enlargement of the pancreas

increased pancreas weight ( J:208604 )

growth/size/body

increased pancreas weight ( J:208604 )