All Phenotypes Nfe2l2<tm1.1Jgpi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nfe2l2^tm1.1Jgpi
targeted mutation 1.1, Jingbo Pi
MGI:5566912

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lep^ob/Lep^ob Nfe2l2^tm1.1Jgpi/Nfe2l2^tm1.1Jgpi Tg(Fabp4-cre)1Rev/0	involves: C57BL/6	MGI:5567001

Allelic Composition	Lep^ob/Lep^ob Nfe2l2^tm1.1Jgpi/Nfe2l2^tm1.1Jgpi Tg(Fabp4-cre)1Rev/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (21 available)
Nfe2l2^tm1.1Jgpi mutation (0 available); any Nfe2l2 mutation (90 available)
Tg(Fabp4-cre)1Rev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208590 )

N	• lipid deposition in the liver and skeletal muscle of mice fed normal chow is the same as in Lep^ob homozygotes

increased circulating glucose level ( J:208590 )

• in mice fed normal chow compared to in Lep^ob homozygotes

increased circulating triglyceride level ( J:208590 )

• in mice fed normal chow compared to in Lep^ob homozygotes

insulin resistance ( J:208590 )

• in mice fed normal chow compared with Lep^ob homozygotes

adipose tissue

decreased white adipose tissue amount ( J:208590 )

• in mice fed normal chow compared to in Lep^ob homozygotes

abnormal white fat cell morphology ( J:208590 )

• fewer small adipocytes in mice fed normal chow compared to in Lep^ob homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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