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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc39a5tm1Gka
targeted mutation 1, Glen K Andrews
MGI:5566985
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Slc39a5tm1Gka/Slc39a5tm1Gka
Tg(Cela1-cre/ERT)1Lgdn/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:5581459
cn2
 		Slc39a5tm1Gka/Slc39a5tm1Gka
Tg(Vil1-cre/ERT2)23Syr/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5581458


Genotype
MGI:5581459
cn1
Allelic
Composition		 Slc39a5tm1Gka/Slc39a5tm1Gka
Tg(Cela1-cre/ERT)1Lgdn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc39a5tm1Gka mutation (1 available); any Slc39a5 mutation (28 available)
Tg(Cela1-cre/ERT)1Lgdn mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Slc39a5tm1Gka/Slc39a5tm1Gka Tg(Cela1-cre/ERT)1Lgdn/0 mice exhibit increased sensitivity to zinc-induced acute pancreatitis

homeostasis/metabolism
decreased liver iron level ( J:209760 )
• in tamoxifen-treated mice
abnormal zinc homeostasis ( J:209760 )
• tamoxifen-treated mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice
• tamoxifen-treated mice fed excess zinc exhibit reduced pancreatic accumulation due to reduced zinc retention compared with control mice
• however, mice exhibit normal pancreatic zinc uptake

endocrine/exocrine glands
pancreatic acinar cell atrophy ( J:209760 )
• in tamoxifen-treated mice exposed to zinc
increased susceptibility to induced pancreatitis ( J:209760 )
• tamoxifen-treated mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice

liver/biliary system
decreased liver iron level ( J:209760 )
• in tamoxifen-treated mice

immune system
increased susceptibility to induced pancreatitis ( J:209760 )
• tamoxifen-treated mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice

digestive/alimentary system
pancreatic acinar cell atrophy ( J:209760 )
• in tamoxifen-treated mice exposed to zinc




Genotype
MGI:5581458
cn2
Allelic
Composition		 Slc39a5tm1Gka/Slc39a5tm1Gka
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc39a5tm1Gka mutation (1 available); any Slc39a5 mutation (28 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal zinc homeostasis ( J:209760 )
• tamoxifen-treated mice provided adequate or excess zinc (by diet or gavage) exhibit increased pancreatic zinc compared with control mice




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory