Analysis Tools
immune system
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• at 8 weeks
• extreme in mice older than 12 months showing signs of disease
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• 3.5-fold at 8 weeks
• 20- to 40-fold in mice older than 12 months showing signs of disease
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• 8 times more in the spleen
• 4-fold in lymph nodes
• increased percent of IgM+IgD+ B cells in the spleen and lymph nodes
• however, absolute numbers in the bone marrow are normal
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• 3 times more in the spleen
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• enlarged
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• prolonged survival in vitro
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• Ig class switch recombination is achieved in the presence of IL4 indicating constitutive CD40 signaling
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• activated B cells in the spleen and lymph node
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• spontaneous
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• activated T cells with a shift toward activated and memory-type T cells
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• in mice older than 12 months showing signs of disease
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• following immunization with hapten conjugated to the carrier chicken gammaglobulin, mice exhibit reduced recruitment/maintenance of B cells within the germinal centers of the spleen compared with wild-type mice
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neoplasm
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• with extreme splenomegaly, enlarged inguinal lymph nodes, hepatomegaly and nodular infiltrates in the kidney, lung and liver in mice older than 12 months showing signs of disease
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liver/biliary system
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• in mice older than 12 months showing signs of disease
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hematopoietic system
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• at 8 weeks
• extreme in mice older than 12 months showing signs of disease
|
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• 3.5-fold at 8 weeks
• 20- to 40-fold in mice older than 12 months showing signs of disease
|
|
• 8 times more in the spleen
• 4-fold in lymph nodes
• increased percent of IgM+IgD+ B cells in the spleen and lymph nodes
• however, absolute numbers in the bone marrow are normal
|
|
• 3 times more in the spleen
|
|
• enlarged
|
|
• prolonged survival in vitro
|
|
• Ig class switch recombination is achieved in the presence of IL4 indicating constitutive CD40 signaling
|
|
• activated B cells in the spleen and lymph node
|
|
• spontaneous
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• activated T cells with a shift toward activated and memory-type T cells
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growth/size/body
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• in mice older than 12 months showing signs of disease
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• at 8 weeks
• extreme in mice older than 12 months showing signs of disease
|
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• 3.5-fold at 8 weeks
• 20- to 40-fold in mice older than 12 months showing signs of disease
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cellular
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• spontaneous
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