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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir10atm1.1Ahl
targeted mutation 1.1, Anders Lund
MGI:5567937
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir10atm1.1Ahl/Mir10atm1.1Ahl B6.129(C)-Mir10atm1.1Ahl MGI:5567979
cx2
 		ApcMin/Apc+
Mir10atm1.1Ahl/Mir10atm1.1Ahl 		B6.Cg-Mir10atm1.1Ahl Apcmin MGI:5567980


Genotype
MGI:5567979
hm1
Allelic
Composition		 Mir10atm1.1Ahl/Mir10atm1.1Ahl
Genetic
Background		 B6.129(C)-Mir10atm1.1Ahl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir10atm1.1Ahl mutation (1 available); any Mir10a mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:205135 )
• mice are exhibit birth in Mendelian ratios, normal growth and development, normal survival and normal susceptibility to spontaneous tumor development




Genotype
MGI:5567980
cx2
Allelic
Composition		 ApcMin/Apc+
Mir10atm1.1Ahl/Mir10atm1.1Ahl
Genetic
Background		 B6.Cg-Mir10atm1.1Ahl Apcmin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Mir10atm1.1Ahl mutation (1 available); any Mir10a mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Enhanced intestinal tumorigenesis in ApcMin/Apc+ Mir10atm1.1Ahl/Mir10atm1.1Ahl mice

neoplasm
increased gastrointestinal tumor incidence ( J:205135 )
• twice as many tumors in the small intestine as in Apcmin heterozygotes
• however, tumor multiplicity in male mice is the same as in Apcmin heterozygotes
increased intestinal adenoma incidence ( J:205135 )
• in the small intestine of female and male mice with increased frequency with of high-grade dysplasia and higher incidence of tubule-villous adenomas (more evident in female mice than male mice)
• however, tumor size is the same as in Apcmin heterozygotes

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:205135 )
• twice as many tumors in the small intestine as in Apcmin heterozygotes
• however, tumor multiplicity in male mice is the same as in Apcmin heterozygotes
increased intestinal adenoma incidence ( J:205135 )
• in the small intestine of female and male mice with increased frequency with of high-grade dysplasia and higher incidence of tubule-villous adenomas (more evident in female mice than male mice)
• however, tumor size is the same as in Apcmin heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory