Phenotypes associated with this allele

• Allele Symbol: Npr2^{tm2.1(cre/ERT2)Fgr}
• Allele Name: targeted mutation 2.1, Fritz G Rathjen
• Allele ID: MGI:5567995
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Npr2^tm2.1(cre/ERT2)Fgr/Npr2^cn Tg(CAG-Bgeo/ALPP)1Lbe/0	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * AKR/J * C57BL/6J	MGI:5568088

Genotype
MGI:5568088

cx1

• Allelic Composition: Npr2^{tm2.1(cre/ERT2)Fgr}/Npr2^cn; Tg(CAG-Bgeo/ALPP)1Lbe/0
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * AKR/J * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:205571 )

N • at E15.5 formation of collaterals by cranial sensory axons is not affected by Npr2 deficiency

N • peripheral processes of the ophthalmic branch of the trigeminal nerve are not significantly affected by Npr2 deficiency

abnormal cranial nerve morphology ( J:205571 )

• at E12.5 axons from cranial sensory ganglia do not bifurcate at the entry zone to the brainstem

abnormal dorsal root ganglion morphology ( J:205571 )

• mice lack axon bifurcation of DRG neurons; axons only exhibit only turns with Npr2 deficiency