Phenotypes associated with this allele

• Allele Symbol: Gabbr2^tm1.1Stmo
• Allele Name: targeted mutation 1.1, Stephen J Moss
• Allele ID: MGI:5568072
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo	involves: 129S2/SvPas * C57BL/6J	MGI:5568073

Genotype
MGI:5568073

hm1

• Allelic Composition: Gabbr2^tm1.1Stmo/Gabbr2^tm1.1Stmo
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus CA1 region morphology ( J:205570 )

• increase in the total number of excitatory synapses in the CA1 striatum radiatum

abnormal synapse morphology ( J:205570 )

• increase in the total number of excitatory synapses in the CA1 striatum radiatum

abnormal hippocampus physiology ( J:205570 )

• cell surface levels of GABBR2 and GABBR1 are increased in hippocampal slices and glutamate-dependent degradation of GABBR2 is abrogated

abnormal synaptic plasticity ( J:205570 )

• enhanced synaptic plasticity

abnormal excitatory postsynaptic currents ( J:205570 )

• increase in current density values for baclofen-activated currents in hippocampal neurons

• basal excitatory synaptic transmissions in CA1 pyramidal neurons are similar to wild-type controls

behavior/neurological

impaired contextual conditioning behavior ( J:205570 )

• decreased freezing in a contextual fear assay

abnormal long-term spatial reference memory ( J:205570 )

• impaired long term spatial memory in a spatial object recognition task and in a Barnes maze